-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 AEsbddRWZLQdX9BsYh9cmZrJXuWfiexk5mHj6SUW26ZjMNBYNg78Gzx0HgK0IlxZ
 gZlld3159s5TWI/HC0zmeg==

<SEC-DOCUMENT>0000812796-09-000010.txt : 20090227
<SEC-HEADER>0000812796-09-000010.hdr.sgml : 20090227
<ACCEPTANCE-DATETIME>20090227100746
ACCESSION NUMBER:		0000812796-09-000010
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090227
DATE AS OF CHANGE:		20090227
EFFECTIVENESS DATE:		20090227

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DOR BIOPHARMA INC
		CENTRAL INDEX KEY:			0000812796
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				411505029
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-81279-6C
		FILM NUMBER:		09640061

	BUSINESS ADDRESS:	
		STREET 1:		850 BEAR TAVERN ROAD
		STREET 2:		SUITE 201
		CITY:			EWING
		STATE:			NJ
		ZIP:			08628
		BUSINESS PHONE:		609-538-8200

	MAIL ADDRESS:	
		STREET 1:		850 BEAR TAVERN ROAD
		STREET 2:		SUITE 201
		CITY:			EWING
		STATE:			NJ
		ZIP:			08628

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ENDOREX CORP
		DATE OF NAME CHANGE:	19960916

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	IMMUNOTHERAPEUTICS INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0201</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000812796</cik>
        <entityName>DOR BIOPHARMA INC</entityName>
        <issuerAddress>
            <street1>850 BEAR TAVERN ROAD</street1>
            <street2>SUITE 201</street2>
            <city>EWING</city>
            <stateOrCountry>NJ</stateOrCountry>
            <zipCode>08628</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>609-538-8200</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>ENDOREX CORP</previousName>
            <previousName>IMMUNOTHERAPEUTICS INC</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <middleName>J</middleName>
                <lastName>Schaber</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>850 Bear Tavern Road</street1>
                <street2>Suite 201</street2>
                <city>Ewing</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08628</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Evan</firstName>
                <middleName></middleName>
                <lastName>Myrainthopoulos</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>850 Bear Tavern Raod</street1>
                <street2>Suite 201</street2>
                <city>Ewing</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08628</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>S</middleName>
                <lastName>Kuo</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>850 Bear Tavern Road</street1>
                <street2>Suite 201</street2>
                <city>Ewing</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08628</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Cyrille</firstName>
                <middleName>F</middleName>
                <lastName>Buhrman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>850 Bear Tavern Road</street1>
                <street2>Suite 201</street2>
                <city>Ewing</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08628</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName></middleName>
                <lastName>Clavijo</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>850 Bea Tavern Road</street1>
                <street2>Suite 201</street2>
                <city>Ewing</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08628</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-02-11</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>4500000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>4500000</totalOfferingAmount>
            <totalAmountSold>4500000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>true</authorizedRepresentative>
            <signature>
                <issuerName>DOR BIOPHARMA INC</issuerName>
                <signatureName>/s/James Clavijo</signatureName>
                <nameOfSigner>James Clavijo</nameOfSigner>
                <signatureTitle>Secretary/Treasurer</signatureTitle>
                <signatureDate>2009-02-27</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----