-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 AS070BFtnLh4x8pfbOV7Tg==

<SEC-DOCUMENT>0000357097-10-000001.txt : 20100329
<SEC-HEADER>0000357097-10-000001.hdr.sgml : 20100329
<ACCEPTANCE-DATETIME>20100329115848
ACCESSION NUMBER:		0000357097-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100329
DATE AS OF CHANGE:		20100329
EFFECTIVENESS DATE:		20100329

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Fibrocell Science, Inc.
		CENTRAL INDEX KEY:			0000357097
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870458888
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-41088
		FILM NUMBER:		10709768

	BUSINESS ADDRESS:	
		STREET 1:		405 EAGLEVIEW BOULEVARD
		CITY:			EXTON
		STATE:			PA
		ZIP:			19341
		BUSINESS PHONE:		484-713-6000

	MAIL ADDRESS:	
		STREET 1:		405 EAGLEVIEW BOULEVARD
		CITY:			EXTON
		STATE:			PA
		ZIP:			19341

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISOLAGEN INC
		DATE OF NAME CHANGE:	20020320

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMERICAN FINANCIAL HOLDING INC /DE
		DATE OF NAME CHANGE:	19960330

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMERICAN FINANCIAL HOLDING INC /CO
		DATE OF NAME CHANGE:	19921008
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000357097</cik>
        <entityName>Fibrocell Science, Inc.</entityName>
        <issuerAddress>
            <street1>405 EAGLEVIEW BOULEVARD</street1>
            <city>EXTON</city>
            <stateOrCountry>PA</stateOrCountry>
            <zipCode>19341</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>484-713-6000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>ISOLAGEN INC</previousName>
            <previousName>AMERICAN FINANCIAL HOLDING INC /DE</previousName>
            <previousName>AMERICAN FINANCIAL HOLDING INC /CO</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Declan</firstName>
                <lastName>Daly</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Fibrocell Science, Inc.</street1>
                <street2>405 Eagleview Boulevard</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Pernock</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Fibrocell Science, Inc.</street1>
                <street2>405 Eagleview Boulevard</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <lastName>Hopper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Fibrocell Science, Inc.</street1>
                <street2>405 Eagleview Road</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Langor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Fibrocell Science, Inc.</street1>
                <street2>405 Eagleview Boulevard</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kelvin</firstName>
                <lastName>Moore</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Fibrocell Science, Inc.</street1>
                <street2>405 Eagleview Boulevard</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-10-13</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>John Carris Investments LLC</recipientName>
                <recipientCRDNumber>145767</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>44 Wall Street</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10005</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CT</state>
                    <state>NY</state>
                    <state>TX</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Viriathus Capital</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>John Carris Investments LLC</associatedBDName>
                <associatedBDCRDNumber>145767</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>2 Rector Street, 16th Floor</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10006</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CT</state>
                    <state>NY</state>
                    <state>TX</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>4880093</totalOfferingAmount>
            <totalAmountSold>4880093</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>11</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>325000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>$325,000 in cash plus Warrants to purchase 250,000 shares at $1.30 share</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Fibrocell Science, Inc.</issuerName>
                <signatureName>Declan Daly</signatureName>
                <nameOfSigner>Declan Daly</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2010-03-29</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----