-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KuSfS5dWFlO74BlHZXACSqa1/TWxppPvaYA+98H9b5NvOY3Kn+1EZWDzFtDOborr
 nC+DVjLv/zNnn+YG9QFJuA==

<SEC-DOCUMENT>0001140361-10-013823.txt : 20100326
<SEC-HEADER>0001140361-10-013823.hdr.sgml : 20100326
<ACCEPTANCE-DATETIME>20100326161318
ACCESSION NUMBER:		0001140361-10-013823
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100326
DATE AS OF CHANGE:		20100326
EFFECTIVENESS DATE:		20100326

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PROVECTUS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000315545
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				900031917
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-13551-D
		FILM NUMBER:		10707861

	BUSINESS ADDRESS:	
		STREET 1:		7327 OAK RIDGE HWY
		STREET 2:		SUITE B
		CITY:			KNOXVILLE
		STATE:			TN
		ZIP:			37931
		BUSINESS PHONE:		865-769-4011

	MAIL ADDRESS:	
		STREET 1:		7327 OAK RIDGE HWY
		STREET 2:		SUITE B
		CITY:			KNOXVILLE
		STATE:			TN
		ZIP:			37931

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ZAMAGE DIGITAL IMAGING INC
		DATE OF NAME CHANGE:	20011126

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SPM GROUP INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000315545</cik>
        <entityName>PROVECTUS PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>7327 OAK RIDGE HWY</street1>
            <street2>SUITE B</street2>
            <city>KNOXVILLE</city>
            <stateOrCountry>TN</stateOrCountry>
            <zipCode>37931</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>865-769-4011</issuerPhoneNumber>
        <jurisdictionOfInc>NEVADA</jurisdictionOfInc>
        <issuerPreviousNameList></issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>ZAMAGE DIGITAL IMAGING INC</previousName>
            <previousName>SPM GROUP INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Timothy</firstName>
                <middleName>C.</middleName>
                <lastName>Scott</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7327 Oak Ridge Highway</street1>
                <street2>Suite A</street2>
                <city>Knoxville</city>
                <stateOrCountry>TN</stateOrCountry>
                <zipCode>37931</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName>R.</middleName>
                <lastName>Culpepper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7327 Oak Ridge Highway</street1>
                <street2>Suite A</street2>
                <city>Knoxville</city>
                <stateOrCountry>TN</stateOrCountry>
                <zipCode>37931</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stuart</firstName>
                <lastName>Fuchs</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7327 Oak Ridge Highway</street1>
                <street2>Suite A</street2>
                <city>Knoxville</city>
                <stateOrCountry>TN</stateOrCountry>
                <zipCode>37931</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kelly</firstName>
                <middleName>M.</middleName>
                <lastName>McMasters</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7327 Oak Ridge Highway</street1>
                <street2>Suite A</street2>
                <city>Knoxville</city>
                <stateOrCountry>TN</stateOrCountry>
                <zipCode>37931</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eric</firstName>
                <middleName>A.</middleName>
                <lastName>Wachter</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7327 Oak Ridge Highway</street1>
                <street2>Suite A</street2>
                <city>Knoxville</city>
                <stateOrCountry>TN</stateOrCountry>
                <zipCode>37931</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Craig</firstName>
                <middleName>H.</middleName>
                <lastName>Dees</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>7327 Oak Ridge Highway</street1>
                <street2>Suite A</street2>
                <city>Knoxville</city>
                <stateOrCountry>TN</stateOrCountry>
                <zipCode>37931</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001140361-09-015475</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-04-07</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Maxim Group LLC</recipientName>
                <recipientCRDNumber>120708</recipientCRDNumber>
                <associatedBDName>NA</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>405 Lexington Avenue</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10174</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>FL</state>
                    <state>IL</state>
                    <state>NJ</state>
                    <state>NY</state>
                    <state>PA</state>
                    <state>PR</state>
                    <state>VA</state>
                    <state>WA</state>
                    <state>WI</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Network 1 Financial Securities, Inc.</recipientName>
                <recipientCRDNumber>13577</recipientCRDNumber>
                <associatedBDName>NA</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>The Galleria Penthouse</street1>
                    <street2>2 Bridge Avenue, Building 2</street2>
                    <city>Red Bank</city>
                    <stateOrCountry>NJ</stateOrCountry>
                    <zipCode>07701</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>FL</state>
                    <state>NJ</state>
                    <state>NY</state>
                    <state>OH</state>
                    <state>OR</state>
                    <state>PA</state>
                    <state>TX</state>
                    <state>VA</state>
                    <state>WI</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>10363327</totalOfferingAmount>
            <totalAmountSold>7613327</totalAmountSold>
            <totalRemaining>2750000</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>90</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>761333</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Commission as shown does not include a non-accountable expense allowance of 3% of gross proceeds and common stock equal to 10% of the total number of shares of common stock issued at closing.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>PROVECTUS PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ Peter R. Culpepper</signatureName>
                <nameOfSigner>Peter R. Culpepper</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2010-03-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----