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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001144204-10-037966.txt : 20100715
<SEC-HEADER>0001144204-10-037966.hdr.sgml : 20100715
<ACCEPTANCE-DATETIME>20100715104217
ACCESSION NUMBER:		0001144204-10-037966
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Investment Company Act Section 3(c)
ITEM INFORMATION:		Section 3(c)(7)
FILED AS OF DATE:		20100715
DATE AS OF CHANGE:		20100715
EFFECTIVENESS DATE:		20100715

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			York Multi-Strategy Institutional Fund, Ltd
		CENTRAL INDEX KEY:			0001496548
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-144997
		FILM NUMBER:		10953439

	BUSINESS ADDRESS:	
		STREET 1:		767 FIFTH AVE
		STREET 2:		17TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10153
		BUSINESS PHONE:		345-949-6770

	MAIL ADDRESS:	
		STREET 1:		P.O.BOX 896GT GARDENIA COURT
		STREET 2:		SUITE 3307 45 MARKET STREET
		CITY:			CAMANA BAY
		STATE:			E9
		ZIP:			KY1-1103
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001496548</cik>
        <entityName>York Multi-Strategy Institutional Fund, Ltd</entityName>
        <issuerAddress>
            <street1>SUITE 3307 45 MARKET STREET</street1>
            <city>CAMANA BAY</city>
            <stateOrCountry>E9</stateOrCountry>
            <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
            <zipCode>KY1-1103</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>345-949-6770</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2010</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dawn</firstName>
                <middleName>E.</middleName>
                <lastName>Davies</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Euro-Dutch Trust Company (Bahamas) Ltd.</street1>
                <street2>Charlotte House, PO Box N-9204</street2>
                <city>Nassau</city>
                <stateOrCountry>C5</stateOrCountry>
                <stateOrCountryDescription>BAHAMAS</stateOrCountryDescription>
                <zipCode>none</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Anthony</firstName>
                <middleName>L.M.</middleName>
                <lastName>Inder Rieden</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Euro-Dutch Trust Company (Bahamas) Ltd.</street1>
                <street2>Charlotte House, PO Box N-9204</street2>
                <city>Nassau</city>
                <stateOrCountry>C5</stateOrCountry>
                <stateOrCountryDescription>BAHAMAS</stateOrCountryDescription>
                <zipCode>none</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>none</firstName>
                <middleName>none</middleName>
                <lastName>York Offshore Holdings, L.L.C.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>767 Fifth Avenue</street1>
                <street2>17th Floor</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10153</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Manager of the Issuer</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-07-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>10000000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>53938835</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse>The reported amount sold is the amount sold in exempt U.S. offering only.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>The Manager of the Issuer will receive certain asset-based fees and may receive performance-based fees and allocations.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>York Multi-Strategy Institutional Fund, Ltd</issuerName>
                <signatureName>/s/ Adam J. Semler</signatureName>
                <nameOfSigner>Adam J. Semler</nameOfSigner>
                <signatureTitle>Chief Operating Officer</signatureTitle>
                <signatureDate>2010-07-15</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----