-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001483471-10-000001.txt : 20100205
<SEC-HEADER>0001483471-10-000001.hdr.sgml : 20100205
<ACCEPTANCE-DATETIME>20100205134715
ACCESSION NUMBER:		0001483471-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100205
DATE AS OF CHANGE:		20100205
EFFECTIVENESS DATE:		20100205

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Ascenta Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001483471
		IRS NUMBER:				562394460
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-138499
		FILM NUMBER:		10576750

	BUSINESS ADDRESS:	
		STREET 1:		101 LINDENWOOD DRIVE, SUITE 405
		CITY:			MALVERN
		STATE:			PA
		ZIP:			19355
		BUSINESS PHONE:		610-408-0301

	MAIL ADDRESS:	
		STREET 1:		101 LINDENWOOD DRIVE, SUITE 405
		CITY:			MALVERN
		STATE:			PA
		ZIP:			19355
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001483471</cik>
        <entityName>Ascenta Therapeutics, Inc.</entityName>
        <issuerAddress>
            <street1>101 LINDENWOOD DRIVE, SUITE 405</street1>
            <city>MALVERN</city>
            <stateOrCountry>PA</stateOrCountry>
            <zipCode>19355</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>610-408-0301</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J. Mel</firstName>
                <lastName>Sorensen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Ascenta Therapeutics, Inc.</street1>
                <street2>101 Lindenwood Drive, Suite 405</street2>
                <city>Malvern</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19355</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Louis</firstName>
                <lastName>Bock</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Scale Venture Partners</street1>
                <street2>950 Tower Lane, Suite 700</street2>
                <city>Foster City</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94404</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Powell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sofinnova Ventures, Inc.</street1>
                <street2>140 Geary Street, 10th Floor</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marc</firstName>
                <lastName>Lippman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>University of Miami</street1>
                <street2>1430 N.W. 11th Avenue, Suite 1001</street2>
                <city>Miami</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33136</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joel</firstName>
                <lastName>Sussman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Ascenta Therapeutics, Inc.</street1>
                <street2>101 Lindenwood Drive, Suite 405</street2>
                <city>Malvern</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19355</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Norman</firstName>
                <lastName>Selby</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Perseus, L.L.C.</street1>
                <street2>1325 Avenue of the Americas, 6th Floor</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10019</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrew</firstName>
                <middleName>E.</middleName>
                <lastName>Senyei</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Enterprise Partners Venture Capital</street1>
                <street2>2223 Avenida de la Playa, Suite 300</street2>
                <city>La Jolla</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92037</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eckard</firstName>
                <lastName>Weber</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Domain Associates, L.L.C.</street1>
                <street2>12481 High Bluff Drive, Suite 150</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92130</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-01-25</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>15001500</totalOfferingAmount>
            <totalAmountSold>1800180</totalAmountSold>
            <totalRemaining>13201320</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>12</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Ascenta Therapeutics, Inc.</issuerName>
                <signatureName>Joel F. Sussman</signatureName>
                <nameOfSigner>Joel F. Sussman</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2010-02-05</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----