-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 RXdGKW13Kg1xOzsdHCEzQY3z7TzC2OhRE0NLHo6ZAeVF9CFkSvXzfDMUoxUxfLb+
 fBFpOGPxaCkY4sr2J/XQoQ==

<SEC-DOCUMENT>0001140361-11-002274.txt : 20110111
<SEC-HEADER>0001140361-11-002274.hdr.sgml : 20110111
<ACCEPTANCE-DATETIME>20110111112259
ACCESSION NUMBER:		0001140361-11-002274
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Section 3(c)(7)
FILED AS OF DATE:		20110111
DATE AS OF CHANGE:		20110111
EFFECTIVENESS DATE:		20110111

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MSD European Opportunity Fund, Ltd.
		CENTRAL INDEX KEY:			0001482255
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-138681
		FILM NUMBER:		11521847

	BUSINESS ADDRESS:	
		STREET 1:		C/O HSBC TRUSTEE (CAYMAN) LIMITED
		STREET 2:		68 WEST BAY ROAD, P.O. BOX 484
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1106
		BUSINESS PHONE:		345-949-9555

	MAIL ADDRESS:	
		STREET 1:		C/O HSBC TRUSTEE (CAYMAN) LIMITED
		STREET 2:		68 WEST BAY ROAD, P.O. BOX 484
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1106
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001482255</cik>
        <entityName>MSD European Opportunity Fund, Ltd.</entityName>
        <issuerAddress>
            <street1>C/O HSBC TRUSTEE (CAYMAN) LIMITED</street1>
            <street2>68 WEST BAY ROAD, P.O. BOX 484</street2>
            <city>GRAND CAYMAN</city>
            <stateOrCountry>E9</stateOrCountry>
            <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
            <zipCode>KY1-1106</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>345-949-9555</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2009</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>C.</middleName>
                <lastName>Phelan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o HSBC Trustee (Cayman) Limited</street1>
                <street2>68 West Bay Road, P.O. Box 484</street2>
                <city>Grand Cayman</city>
                <stateOrCountry>E9</stateOrCountry>
                <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
                <zipCode>KY1-1106</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>M.</middleName>
                <lastName>Makin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o HSBC Trustee (Cayman) Limited</street1>
                <street2>68 West Bay Road, P.O. Box 484</street2>
                <city>Grand Cayman</city>
                <stateOrCountry>E9</stateOrCountry>
                <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
                <zipCode>KY1-1106</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tammy</firstName>
                <lastName>Jennissen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o HSBC Trustee (Cayman) Limited</street1>
                <street2>68 West Bay Road, P.O. Box 484</street2>
                <city>Grand Cayman</city>
                <stateOrCountry>E9</stateOrCountry>
                <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
                <zipCode>KY1-1106</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000902664-10-000578</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-02-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>100000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>BTIG, LLC</recipientName>
                <recipientCRDNumber>122225</recipientCRDNumber>
                <associatedBDName>Fusion Partners</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>450 Sansome Street</street1>
                    <city>San Francisco</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                    <zipCode>94111</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NY</state>
                    <description>NEW YORK</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>89300000</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>6</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>46875</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>The placement agent's commissions are equal to a percentage of the management fees attributable to the investors it introduces to the Issuer.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>The fund charges a management fee that is described in the fund's offering documents.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>MSD European Opportunity Fund, Ltd.</issuerName>
                <signatureName>/s/ Marc R. Lisker</signatureName>
                <nameOfSigner>Marc R. Lisker</nameOfSigner>
                <signatureTitle>Managing Director of the GP of the Investment Manager</signatureTitle>
                <signatureDate>2011-01-07</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----