<SEC-DOCUMENT>0001472225-13-000001.txt : 20130128
<SEC-HEADER>0001472225-13-000001.hdr.sgml : 20130128
<ACCEPTANCE-DATETIME>20130125174245
ACCESSION NUMBER:		0001472225-13-000001
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Investment Company Act Section 3(c)
ITEM INFORMATION:		Section 3(c)(1)
FILED AS OF DATE:		20130128
DATE AS OF CHANGE:		20130125
EFFECTIVENESS DATE:		20130128

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Redmile Special Opportunities Fund, Ltd.
		CENTRAL INDEX KEY:			0001472225
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-134870
		FILM NUMBER:		13549703

	BUSINESS ADDRESS:	
		STREET 1:		C/O APPLEBY TRUST (CAYMAN) LTD.
		STREET 2:		CLIFTON HOUSE, 75 FORT STREET, BOX 1350
		CITY:			GRAND CAYMAN KY1-1108
		STATE:			E9
		ZIP:			BWI
		BUSINESS PHONE:		415-677-5340

	MAIL ADDRESS:	
		STREET 1:		C/O APPLEBY TRUST (CAYMAN) LTD.
		STREET 2:		CLIFTON HOUSE, 75 FORT STREET, BOX 1350
		CITY:			GRAND CAYMAN KY1-1108
		STATE:			E9
		ZIP:			BWI

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Redmile Ventures, Ltd.
		DATE OF NAME CHANGE:	20090914
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0706</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001472225</cik>
        <entityName>Redmile Special Opportunities Fund, Ltd.</entityName>
        <issuerAddress>
            <street1>C/O APPLEBY TRUST (CAYMAN) LTD.</street1>
            <street2>CLIFTON HOUSE, 75 FORT STREET, BOX 1350</street2>
            <city>GRAND CAYMAN KY1-1108</city>
            <stateOrCountry>E9</stateOrCountry>
            <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
            <zipCode>BWI</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>415-677-5340</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Redmile Ventures, Ltd.</previousName>
        </edgarPreviousNameList>
        <entityType>Other</entityType>
        <entityTypeOtherDesc>Cayman Islands Exempted Company</entityTypeOtherDesc>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2009</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeremy</firstName>
                <lastName>Green</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Redmile Group, LLC</street1>
                <street2>One Letterman Drive, Bldg D, Suite D3-70</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94129</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Jeremy Green is an executive officer of Redmile Group, LLC, the Investment Manager of the Issuer.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Josh</firstName>
                <lastName>Garcia</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Redmile Group, LLC</street1>
                <street2>One Letterman Drive, Bldg D, Suite D3-70</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94129</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Josh Garcia is an executive officer of Redmile Group, LLC, the Investment Manager of the Issuer.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>N/A</firstName>
                <lastName>Redmile Group, LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Letterman Drive, Bldg D, Suite D3-70</street1>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94129</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Investment Manager of the Issuer</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.1</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001472225-12-000002</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-07-28</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>1000000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>9272852</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>22</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>The Investment Manager (or its affiliate) is entitled to receive a management fee in an amount equal to a specified percentage of assets under management.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Redmile Special Opportunities Fund, Ltd.</issuerName>
                <signatureName>/s/ Jeremy Green</signatureName>
                <nameOfSigner>Jeremy Green</nameOfSigner>
                <signatureTitle>Authorized Person</signatureTitle>
                <signatureDate>2013-01-25</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>