-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 uPAKN/gKkvGwNcPaY4KjKw==

<SEC-DOCUMENT>0001467652-09-000006.txt : 20091123
<SEC-HEADER>0001467652-09-000006.hdr.sgml : 20091123
<ACCEPTANCE-DATETIME>20091123155118
ACCESSION NUMBER:		0001467652-09-000006
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091123
DATE AS OF CHANGE:		20091123
EFFECTIVENESS DATE:		20091123

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Neos Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001467652
		IRS NUMBER:				270395455
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-132428
		FILM NUMBER:		091201713

	BUSINESS ADDRESS:	
		STREET 1:		2940 N. HIGHWAY 360
		STREET 2:		SUITE 100
		CITY:			GRAND PRAIRIE
		STATE:			TX
		ZIP:			75050
		BUSINESS PHONE:		972.408.1360

	MAIL ADDRESS:	
		STREET 1:		2940 N. HIGHWAY 360
		STREET 2:		SUITE 100
		CITY:			GRAND PRAIRIE
		STATE:			TX
		ZIP:			75050
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001467652</cik>
        <entityName>Neos Therapeutics, Inc.</entityName>
        <issuerAddress>
            <street1>2940 N. HIGHWAY 360</street1>
            <street2>SUITE 100</street2>
            <city>GRAND PRAIRIE</city>
            <stateOrCountry>TX</stateOrCountry>
            <zipCode>75050</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>972.408.1360</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
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        <edgarPreviousNameList>
            <value>None</value>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2009</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <lastName>Tengler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ralph</firstName>
                <lastName>Iannelli</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Greg</firstName>
                <lastName>Robitaille</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alan</firstName>
                <lastName>Heller</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bryant</firstName>
                <lastName>Fong</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Arlen</firstName>
                <lastName>Ewart</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Russ</firstName>
                <lastName>McMahen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Margaret</firstName>
                <lastName>Lokash</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bryan</firstName>
                <lastName>Hill</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Clark</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Chris</firstName>
                <lastName>Clement</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Karl</firstName>
                <lastName>Handelsman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2940 N. Highway 360</street1>
                <street2>Suite 100</street2>
                <city>Grand Prairie</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001467652-09-000005</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-06-19</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Salem Partners LLC</recipientName>
                <recipientCRDNumber>43363</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>11111 Santa Monica Blvd.</street1>
                    <street2>Suite 1070</street2>
                    <city>Los Angeles</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>90025</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>FL</state>
                    <state>IL</state>
                    <state>MI</state>
                    <state>PA</state>
                    <state>TX</state>
                    <state>WY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>50000000</totalOfferingAmount>
            <totalAmountSold>24195000</totalAmountSold>
            <totalRemaining>25805000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>57</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>1426700</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Neos Therapeutics, Inc.</issuerName>
                <signatureName>/s/Mark Tengler/</signatureName>
                <nameOfSigner>Mark Tengler</nameOfSigner>
                <signatureTitle>Co-President and CTO</signatureTitle>
                <signatureDate>2009-11-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----