-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TuofHDB0uqNvXhm4wPH0HnNSlIGSEEl6bXJgQNj2O5aVgXaeS16wBO3UcleQ3sEW
 MyD9sz21+8Xep/OkRadFug==

<SEC-DOCUMENT>0001467054-09-000001.txt : 20091113
<SEC-HEADER>0001467054-09-000001.hdr.sgml : 20091113
<ACCEPTANCE-DATETIME>20091112203433
ACCESSION NUMBER:		0001467054-09-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091113
DATE AS OF CHANGE:		20091112
EFFECTIVENESS DATE:		20091113

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MedKnowledge Investors II, LP
		CENTRAL INDEX KEY:			0001467054
		IRS NUMBER:				263734245
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-136090
		FILM NUMBER:		091178885

	BUSINESS ADDRESS:	
		STREET 1:		10877 WILSHIRE BLVD
		STREET 2:		12TH FLOOR
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90024
		BUSINESS PHONE:		310-943-4990

	MAIL ADDRESS:	
		STREET 1:		10877 WILSHIRE BLVD
		STREET 2:		12TH FLOOR
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90024
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001467054</cik>
        <entityName>MedKnowledge Investors II, LP</entityName>
        <issuerAddress>
            <street1>10877 WILSHIRE BLVD</street1>
            <street2>12TH FLOOR</street2>
            <city>LOS ANGELES</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>90024</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>310-943-4990</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>None</firstName>
                <middleName>None</middleName>
                <lastName>TPCP Investment XX, LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10877 Wilshire Blvd, 12th Floor</street1>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90024</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>General Partner of issuer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>None</firstName>
                <middleName>None</middleName>
                <lastName>Triton Pacific Capital Partners, LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10877 Wilshire Blvd., 12th Floor</street1>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90024</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Craig</firstName>
                <middleName>J.</middleName>
                <lastName>Faggen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10877 Wilshire Blvd., 12th Floor</street1>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90024</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ivan</firstName>
                <middleName>None</middleName>
                <lastName>Faggen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10877 Wilshire Blvd., 12th Floor</street1>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90024</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>L.</middleName>
                <lastName>Carroll</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>10877 Wilshire Blvd., 12th Floor</street1>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90024</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Investing</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-12-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Triton Pacific Securities, LLC</recipientName>
                <recipientCRDNumber>139919</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>10877 Wilshire Blvd., 12th Floor</street1>
                    <city>Los Angeles</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>90024</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>FL</state>
                    <state>TN</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>6850000</totalOfferingAmount>
            <totalAmountSold>6850000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>13</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>31530</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Paid to broker which is related to issuer.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>300000</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>MedKnowledge Investors II, LP</issuerName>
                <signatureName>Michael L. Carroll</signatureName>
                <nameOfSigner>Michael L. Carroll</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2009-11-12</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----