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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 RHLqZrUow8twjucTTcY+1Q==

<SEC-DOCUMENT>0001458445-10-000002.txt : 20100831
<SEC-HEADER>0001458445-10-000002.hdr.sgml : 20100831
<ACCEPTANCE-DATETIME>20100831150054
ACCESSION NUMBER:		0001458445-10-000002
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Investment Company Act Section 3(c)
ITEM INFORMATION:		Section 3(c)(7)
FILED AS OF DATE:		20100831
DATE AS OF CHANGE:		20100831
EFFECTIVENESS DATE:		20100831

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SEI Offshore Advanced Strategy Series SPC, Structured Credit Portfolio
		CENTRAL INDEX KEY:			0001458445
		IRS NUMBER:				980614906
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-127795
		FILM NUMBER:		101049851

	BUSINESS ADDRESS:	
		STREET 1:		UGLAND HOUSE, SOUTH CHURCH STREET
		STREET 2:		PO BOX 309 GT
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1202
		BUSINESS PHONE:		610-676-1000

	MAIL ADDRESS:	
		STREET 1:		C/O SEI INVESTMENTS
		STREET 2:		ONE FREEDOM VALLEY DRIVE
		CITY:			OAKS
		STATE:			PA
		ZIP:			19456
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001458445</cik>
        <entityName>SEI Offshore Advanced Strategy Series SPC, Structured Credit Portfolio</entityName>
        <issuerAddress>
            <street1>One Freedom Valley Drive</street1>
            <city>Oaks</city>
            <stateOrCountry>PA</stateOrCountry>
            <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
            <zipCode>19456</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>610-676-2269</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2007</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SEI</firstName>
                <lastName>Funds, Inc.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Freedom Valley Drive</street1>
                <city>Oaks</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19456</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tilly</firstName>
                <lastName>Directors Limited</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Harbour Place, 5th Floor</street1>
                <street2>South Church Street</street2>
                <city>Grand Cayman</city>
                <stateOrCountry>E9</stateOrCountry>
                <stateOrCountryDescription>CAYMAN ISLANDS</stateOrCountryDescription>
                <zipCode>KY1-1202</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SEI</firstName>
                <lastName>Investments Management Corporation</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Freedom Valley Drive</street1>
                <city>Oaks</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19456</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001209191-09-042902</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2007-08-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>220809741</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>11</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>7500</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Annual Director's fee.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>SEI Offshore Advanced Strategy Series SPC, Structured Credit Portfolio</issuerName>
                <signatureName>James Ndiaye</signatureName>
                <nameOfSigner>James Ndiaye</nameOfSigner>
                <signatureTitle>Vice-President of SEI Funds, Inc. - Director</signatureTitle>
                <signatureDate>2010-08-31</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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