-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 G44lyRnyDLsPeb+8qJv/Iy3G43H9zAqwZzv9fERDXQroJhQj0sfsY0VcTa+3DqPn
 Ls2pxnXqiLTyVrKZCwLK3Q==

<SEC-DOCUMENT>0001456303-09-000005.txt : 20090616
<SEC-HEADER>0001456303-09-000005.hdr.sgml : 20090616
<ACCEPTANCE-DATETIME>20090615181554
ACCESSION NUMBER:		0001456303-09-000005
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090616
DATE AS OF CHANGE:		20090615
EFFECTIVENESS DATE:		20090616

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INVESTBIO VENTURES - AMPLIMED IV, L.P.
		CENTRAL INDEX KEY:			0001456303
		IRS NUMBER:				262981020
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-126978
		FILM NUMBER:		09892859

	BUSINESS ADDRESS:	
		STREET 1:		135 FIFTH AVENUE
		STREET 2:		10TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10010
		BUSINESS PHONE:		212-739-7700

	MAIL ADDRESS:	
		STREET 1:		135 FIFTH AVENUE
		STREET 2:		10TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INVESTBIO VENTURES - AMPLIMED REVERSE MERGER LP
		DATE OF NAME CHANGE:	20090213
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0401</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001456303</cik>
        <entityName>INVESTBIO VENTURES - AMPLIMED IV, L.P.</entityName>
        <issuerAddress>
            <street1>135 FIFTH AVENUE</street1>
            <street2>10TH FLOOR</street2>
            <city>NEW YORK</city>
            <stateOrCountry>NY</stateOrCountry>
            <zipCode>10010</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>212-739-7700</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>INVESTBIO VENTURES - AMPLIMED REVERSE MERGER LP</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Scott</firstName>
                <middleName>L</middleName>
                <lastName>Mathis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>135 Fifth Avenue</street1>
                <street2>10th Floor</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10010</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Scott L. Mathis is the President of InvestBio Ventures - AmpliMed, LLC, a Delaware limited liability company, which is the General Partner of InvestBio Ventures - AmpliMed IV, L.P.</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ronald</firstName>
                <middleName>S</middleName>
                <lastName>Robbins</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>135 Fifth Avenue</street1>
                <street2>10th Floor</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10010</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Ronald S. Robbins is the Executive Vice-President of InvestBio Ventures - AmpliMed, LLC, a Delaware limited liability company, which is the General Partner of InvestBio Ventures - AmpliMed IV, L.P.</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Investing</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-09-004030</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-01-23</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Limited Partnership Interests</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>60000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>DPEC Capital, Inc.</recipientName>
                <recipientCRDNumber>103737</recipientCRDNumber>
                <associatedBDName>DPEC Capital, Inc.</associatedBDName>
                <associatedBDCRDNumber>103737</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>135 Fifth Avenue</street1>
                    <street2>10th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10010</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>FL</state>
                    <state>IL</state>
                    <state>MA</state>
                    <state>MN</state>
                    <state>NJ</state>
                    <state>NY</state>
                    <state>PA</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1068032</totalOfferingAmount>
            <totalAmountSold>1068032</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Offering is closed.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>24</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>106803</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>INVESTBIO VENTURES - AMPLIMED IV, L.P.</issuerName>
                <signatureName>/s/Scott L. Mathis</signatureName>
                <nameOfSigner>Scott L. Mathis</nameOfSigner>
                <signatureTitle>President of General Partner</signatureTitle>
                <signatureDate>2009-06-15</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----