-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 FWKlshesC7HR1xsprvXPoZB7qouX97r5jwmGRKs7ma14IHn678aOMudY7uMeGPAx
 XoQkdOszDD3nm3uCl9DYrA==

<SEC-DOCUMENT>0001255294-09-000315.txt : 20090521
<SEC-HEADER>0001255294-09-000315.hdr.sgml : 20090521
<ACCEPTANCE-DATETIME>20090521140530
ACCESSION NUMBER:		0001255294-09-000315
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090521
DATE AS OF CHANGE:		20090521
EFFECTIVENESS DATE:		20090521

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OptimizeRx Corp
		CENTRAL INDEX KEY:			0001448431
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-BUSINESS SERVICES, NEC [7389]
		IRS NUMBER:				261265381
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-131412
		FILM NUMBER:		09844961

	BUSINESS ADDRESS:	
		STREET 1:		407 SIXTH STREET
		CITY:			ROCHESTER
		STATE:			MI
		ZIP:			48307
		BUSINESS PHONE:		248-651-6558

	MAIL ADDRESS:	
		STREET 1:		407 SIXTH STREET
		CITY:			ROCHESTER
		STATE:			MI
		ZIP:			48307
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001448431</cik>
        <entityName>OptimizeRx Corp</entityName>
        <issuerAddress>
            <street1>407 SIXTH STREET</street1>
            <street2></street2>
            <city>ROCHESTER</city>
            <stateOrCountry>MI</stateOrCountry>
            <zipCode>48307</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>248-651-6558</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>NV</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Lester</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>407 Sixth Street</street1>
                <street2></street2>
                <city>Rochester</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48307</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Harrell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>407 Sixth Street</street1>
                <street2></street2>
                <city>Rochester</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48307</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName></middleName>
                <lastName>Majerowicz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>407 Sixth Street</street1>
                <street2></street2>
                <city>Rochester</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48307</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Terrence</firstName>
                <middleName></middleName>
                <lastName>Hamilton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>407 Sixth Street</street1>
                <street2></street2>
                <city>Rochester</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48307</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Business Services</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-09-08</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Midtown Partners</recipientName>
                <recipientCRDNumber>104223</recipientCRDNumber>
                <associatedBDName>Midtown Partners</associatedBDName>
                <associatedBDCRDNumber>104223</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>4218 West Linebaugh Avenue</street1>
                    <street2></street2>
                    <city>Tampa</city>
                    <stateOrCountry>FL</stateOrCountry>
                    <zipCode>33624</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3500000</totalOfferingAmount>
            <totalAmountSold>3500000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>350000</dollarAmount>
            </findersFees>
            <clarificationOfResponse>The Company paid finder's fees of $350,000 and issued 7 year warrants to purchase 600,000 shares at $2.00 per share and 7 year warrants to purchase 350,000 shares at $1.00 per share</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>OptimizeRx Corp</issuerName>
                <signatureName>/s/H David Lester</signatureName>
                <nameOfSigner>H. David Lester</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2009-05-21</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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