-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 UuYtSO5VmQ4N8dX0/NVGSWGHlFMkN8wd4z/6QxMXDuVPn+QZGK37gkm4c8lD+MXK
 7y8gVUs6w45ftWShONh62Q==

<SEC-DOCUMENT>0001470566-09-000001.txt : 20090903
<SEC-HEADER>0001470566-09-000001.hdr.sgml : 20090903
<ACCEPTANCE-DATETIME>20090903161550
ACCESSION NUMBER:		0001470566-09-000001
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090903
DATE AS OF CHANGE:		20090903
EFFECTIVENESS DATE:		20090903

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IRONWOOD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001446847
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-123103
		FILM NUMBER:		091053868

	BUSINESS ADDRESS:	
		STREET 1:		320 BENT STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
		BUSINESS PHONE:		617-621-7722

	MAIL ADDRESS:	
		STREET 1:		320 BENT STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001446847</cik>
        <entityName>IRONWOOD PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>320 BENT STREET</street1>
            <street2></street2>
            <city>CAMBRIDGE</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>02141</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>617-621-7722</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <middleName></middleName>
                <lastName>EBERSMAN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>PETER</firstName>
                <middleName>M.</middleName>
                <lastName>HECHT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MICHAEL</firstName>
                <middleName>J.</middleName>
                <lastName>HIGGINS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JOSEPH</firstName>
                <middleName>C.</middleName>
                <lastName>COOK, JR.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>STEPHEN</firstName>
                <middleName></middleName>
                <lastName>KNIGHT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>TERRANCE</firstName>
                <middleName>G.</middleName>
                <lastName>MCGUIRE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GINA</firstName>
                <middleName>BORNINO</middleName>
                <lastName>MILLER</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>BRYAN</firstName>
                <middleName>E.</middleName>
                <lastName>ROBERTS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>CHRISTOPHER</firstName>
                <middleName>T.</middleName>
                <lastName>WALSH</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DAVID</firstName>
                <middleName></middleName>
                <lastName>SHAW</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GEORGE</firstName>
                <middleName>H.</middleName>
                <lastName>CONRADES</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MARK</firstName>
                <middleName>G.</middleName>
                <lastName>CURRIE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O IRONWOOD PHARMACEUTICALS, INC.</street1>
                <street2>320 BENT STREET</street2>
                <city>CAMBRIDGE</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02141</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001446847-09-000002</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-08-17</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>249996</totalOfferingAmount>
            <totalAmountSold>249996</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>IRONWOOD PHARMACEUTICALS INC</issuerName>
                <signatureName>HALLEY GILBERT</signatureName>
                <nameOfSigner>HALLEY GILBERT</nameOfSigner>
                <signatureTitle>GENERAL COUNSEL</signatureTitle>
                <signatureDate>2009-09-03</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----