-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 LlsG+GGvbuicPoNKKtaDQlv0VMLGBX5dhRzKCmOny0yAmlViFtmyfKfWp7CTQqW6
 W9MFzIATam9+iklYRb6hfg==

<SEC-DOCUMENT>0001445499-10-000001.txt : 20100121
<SEC-HEADER>0001445499-10-000001.hdr.sgml : 20100121
<ACCEPTANCE-DATETIME>20100121145022
ACCESSION NUMBER:		0001445499-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100121
DATE AS OF CHANGE:		20100121
EFFECTIVENESS DATE:		20100121

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IMPEL NEUROPHARMA INC
		CENTRAL INDEX KEY:			0001445499
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-122600
		FILM NUMBER:		10538703

	BUSINESS ADDRESS:	
		STREET 1:		867 SW SHOREMONT AVE
		CITY:			NORMANDY PARK
		STATE:			WA
		ZIP:			98166
		BUSINESS PHONE:		408-966-9981

	MAIL ADDRESS:	
		STREET 1:		867 SW SHOREMONT AVE
		CITY:			NORMANDY PARK
		STATE:			WA
		ZIP:			98166
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001445499</cik>
        <entityName>IMPEL NEUROPHARMA INC</entityName>
        <issuerAddress>
            <street1>867 SW SHOREMONT AVE</street1>
            <city>NORMANDY PARK</city>
            <stateOrCountry>WA</stateOrCountry>
            <zipCode>98166</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>408-966-9981</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>P.</middleName>
                <lastName>Hite</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Impel NeuroPharma, Inc.</street1>
                <street2>867 SW Shoremont Ave.</street2>
                <city>Normandy Park</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98166</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>D.</middleName>
                <lastName>Hoekman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Impel NeuroPharma, Inc.</street1>
                <street2>867 SW Shoremont Ave.</street2>
                <city>Normandy Park</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98166</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Rodney</firstName>
                <lastName>Ho</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Impel NeuroPharma, Inc.</street1>
                <street2>867 SW Shoremont Ave.</street2>
                <city>Normandy Park</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98166</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-01-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>25000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1543553</totalOfferingAmount>
            <totalAmountSold>305364</totalAmountSold>
            <totalRemaining>1238189</totalRemaining>
            <clarificationOfResponse>None of the warrants issued in connection with the financing have been exercised.  The company has therefore not received proceeds from the exercise of the warrants, if ever.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>7</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>IMPEL NEUROPHARMA INC</issuerName>
                <signatureName>/s/ MICHAEL P. HITE</signatureName>
                <nameOfSigner>Michael P. Hite</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2010-01-19</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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