-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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MIC-Info: RSA-MD5,RSA,
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 ZyIZOcL4yowYBiBNehHQsA==

<SEC-DOCUMENT>0001444253-10-000001.txt : 20100406
<SEC-HEADER>0001444253-10-000001.hdr.sgml : 20100406
<ACCEPTANCE-DATETIME>20100406121251
ACCESSION NUMBER:		0001444253-10-000001
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100406
DATE AS OF CHANGE:		20100406
EFFECTIVENESS DATE:		20100406

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PROFECTUS BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001444253
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-122114
		FILM NUMBER:		10733592

	BUSINESS ADDRESS:	
		STREET 1:		6411 BECKLEY STREET
		STREET 2:		SUITE N202
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		443-524-0843

	MAIL ADDRESS:	
		STREET 1:		6411 BECKLEY STREET
		STREET 2:		SUITE N202
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001444253</cik>
        <entityName>PROFECTUS BIOSCIENCES INC</entityName>
        <issuerAddress>
            <street1>6411 BECKLEY STREET</street1>
            <street2>SUITE N202</street2>
            <city>BALTIMORE</city>
            <stateOrCountry>MD</stateOrCountry>
            <zipCode>21224</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>443-743-1100</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Maryland Biotherapeutics Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeffrey</firstName>
                <lastName>Meshulam</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, Suite N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <lastName>Adamsky</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joseph</firstName>
                <lastName>Berardino</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>A</middleName>
                <lastName>Haseltine</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckly Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>G.</middleName>
                <lastName>Paese</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>M.G.</firstName>
                <lastName>Sarngadharan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stewart</firstName>
                <lastName>Greenebaum</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Lynch</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alexander</firstName>
                <lastName>Rich</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Frederick</firstName>
                <middleName>C.</middleName>
                <lastName>Tecce</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6411 Beckley Street, N201</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21224</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001444253-09-000003</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-07-20</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>6041205</totalOfferingAmount>
            <totalAmountSold>6041205</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>PROFECTUS BIOSCIENCES INC</issuerName>
                <signatureName>Jeffrey Meshulam</signatureName>
                <nameOfSigner>Jeffrey Meshulam</nameOfSigner>
                <signatureTitle>Vice President, Chief Operating Officer and Secretary</signatureTitle>
                <signatureDate>2010-04-06</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----