-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 H4ZnXXKwFlD2rZCEivcb3GoBp7B3a3CstKhR2YdB5+t+rxt3TbvS+kwkJhIfk4ue
 nc0/O+kfEycVi2llYyhJyw==

<SEC-DOCUMENT>0001181431-10-052593.txt : 20101101
<SEC-HEADER>0001181431-10-052593.hdr.sgml : 20101101
<ACCEPTANCE-DATETIME>20101101124216
ACCESSION NUMBER:		0001181431-10-052593
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20101101
DATE AS OF CHANGE:		20101101
EFFECTIVENESS DATE:		20101101

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NXTHERA INC
		CENTRAL INDEX KEY:			0001436280
		IRS NUMBER:				262371404
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-145801
		FILM NUMBER:		101154083

	BUSINESS ADDRESS:	
		STREET 1:		4186 LEXINGTON AVENUE
		CITY:			ST PAUL
		STATE:			MN
		ZIP:			55126
		BUSINESS PHONE:		651-484-6095

	MAIL ADDRESS:	
		STREET 1:		4186 LEXINGTON AVENUE
		CITY:			ST PAUL
		STATE:			MN
		ZIP:			55126
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001436280</cik>
        <entityName>NXTHERA INC</entityName>
        <issuerAddress>
            <street1>4186 Lexington Avenue</street1>
            <city>St Paul</city>
            <stateOrCountry>MN</stateOrCountry>
            <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
            <zipCode>55126</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>651-484-6095</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J. Robert</firstName>
                <lastName>Paulson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NxThera, Inc.</street1>
                <street2>4186 Lexington Avenue</street2>
                <city>St. Paul</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55126</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Hoey</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NxThera, Inc.</street1>
                <street2>4186 Lexington Avenue</street2>
                <city>St. Paul</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55126</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jan</firstName>
                <lastName>Garfinkle</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Arboretum Ventures</street1>
                <street2>303 Detroit Street, Suite 301</street2>
                <city>Ann Arbor</city>
                <stateOrCountry>MI</stateOrCountry>
                <stateOrCountryDescription>MICHIGAN</stateOrCountryDescription>
                <zipCode>48104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Sami</firstName>
                <lastName>Hamade</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Aberdare Ventures</street1>
                <street2>One Embarcadero Center, Suite 4000</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94111</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andre</firstName>
                <lastName>de Bruin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/oNxThera Inc.</street1>
                <street2>4186 Lexington Avenue</street2>
                <city>St. Paul</city>
                <stateOrCountry>MN</stateOrCountry>
                <stateOrCountryDescription>MINNESOTA</stateOrCountryDescription>
                <zipCode>55126</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001181431-10-039564</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-07-23</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Convertible Promissory Notes and Warrants convertible into future class of Preferred Stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2000000</totalOfferingAmount>
            <totalAmountSold>2000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Amendment is being filed to increase the Total Offering Amount and Total Amount Sold pursuant to a second closing.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>true</authorizedRepresentative>
            <signature>
                <issuerName>NxThera Inc</issuerName>
                <signatureName>/s/ J. Robert Paulson</signatureName>
                <nameOfSigner>J. Robert Paulson</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2010-10-29</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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