-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Vx6s9kHVjI8k4xR85d6PNKjuaRYV6/LA0aMLzMhLFUeD/qPObOwAxDNNRpn9uA1M
 0cdVy4bE+QdBdrjt0H9XDQ==

<SEC-DOCUMENT>0001432580-10-000003.txt : 20100811
<SEC-HEADER>0001432580-10-000003.hdr.sgml : 20100811
<ACCEPTANCE-DATETIME>20100811123038
ACCESSION NUMBER:		0001432580-10-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100811
DATE AS OF CHANGE:		20100811
EFFECTIVENESS DATE:		20100811

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NUON THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001432580
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-146233
		FILM NUMBER:		101007198

	BUSINESS ADDRESS:	
		STREET 1:		2755 CAMPUS DRIVE
		STREET 2:		SUITE 175
		CITY:			SAN MATEO
		STATE:			CA
		ZIP:			94403
		BUSINESS PHONE:		650-645-1800

	MAIL ADDRESS:	
		STREET 1:		2755 CAMPUS DRIVE
		STREET 2:		SUITE 175
		CITY:			SAN MATEO
		STATE:			CA
		ZIP:			94403
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001432580</cik>
        <entityName>NUON THERAPEUTICS INC</entityName>
        <issuerAddress>
            <street1>2755 CAMPUS DRIVE</street1>
            <street2>SUITE 175</street2>
            <city>SAN MATEO</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>94403</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>650-645-1800</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2007</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Lee</firstName>
                <lastName>Rauch</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Nuon Therapeutics, Inc.</street1>
                <street2>2755 Campus Drive, Suite 175</street2>
                <city>San Mateo</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94403</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joshua</firstName>
                <lastName>Funder</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o GBS Venture Partners</street1>
                <street2>Level 5, 71 Collins Street</street2>
                <city>Melbourne</city>
                <stateOrCountry>C3</stateOrCountry>
                <stateOrCountryDescription>AUSTRALIA</stateOrCountryDescription>
                <zipCode>VIC 3000</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kim</firstName>
                <lastName>Kamdar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Domain Associates, L.L.C.</street1>
                <street2>One Palmer Square, Suite 515</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08542</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>More</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o FHM V, LP</street1>
                <street2>601 Union, Two Union Square, Suite 3200</street2>
                <city>Seattle</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Arlene</firstName>
                <lastName>Morris</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Affymax Inc.</street1>
                <street2>4001 Miranda Ave.</street2>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94304</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Helen</firstName>
                <lastName>Jenkins</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Nuon Therapeutics, Inc.</street1>
                <street2>2755 Campus Drive, Suite 175</street2>
                <city>San Mateo</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94403</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Kitt</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Nuon Therapeutics, Inc.</street1>
                <street2>2755 Campus Drive, Suite 175</street2>
                <city>San Mateo</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94403</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tito</firstName>
                <lastName>Serafini</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Nuon Therapeutics, Inc.</street1>
                <street2>2755 Campus Drive, Suite 175</street2>
                <city>San Mateo</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94403</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paulette</firstName>
                <lastName>Dillon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Nuon Therapeutics, Inc.</street1>
                <street2>2755 Campus Drive, Suite 175</street2>
                <city>San Mateo</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94403</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-08-05</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Sale and issuance of (i) convertible promissory notes, convertible into shares of Equity Securities, (ii) warrants exercisable for Series B Preferred Stock, and (iii) the underlying shares of common stock issuable upon conversion of (i) and (ii)</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>9999999</totalOfferingAmount>
            <totalAmountSold>9999999</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>9</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>NUON THERAPEUTICS INC</issuerName>
                <signatureName>Lee Rauch</signatureName>
                <nameOfSigner>Lee Rauch</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2010-08-09</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----