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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001181431-10-015400.txt : 20100311
<SEC-HEADER>0001181431-10-015400.hdr.sgml : 20100311
<ACCEPTANCE-DATETIME>20100311094632
ACCESSION NUMBER:		0001181431-10-015400
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Investment Company Act Section 3(c)
ITEM INFORMATION:		Section 3(c)(7)
FILED AS OF DATE:		20100311
DATE AS OF CHANGE:		20100311
EFFECTIVENESS DATE:		20100311

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRAMERICA ALPHA FIXED INCOME OPPORTUNITY FUND (CAYMAN) SPC, LTD.
		CENTRAL INDEX KEY:			0001430172
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			E9

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-115973
		FILM NUMBER:		10672574

	BUSINESS ADDRESS:	
		STREET 1:		PRUDENTIAL INVESTMENT MANAGEMENT, INC.
		STREET 2:		TWO GATEWAY CENTER, THIRD FLOOR
		CITY:			NEWARK
		STATE:			NJ
		ZIP:			07102
		BUSINESS PHONE:		973-802-5702

	MAIL ADDRESS:	
		STREET 1:		PRUDENTIAL INVESTMENT MANAGEMENT, INC.
		STREET 2:		TWO GATEWAY CENTER, THIRD FLOOR
		CITY:			NEWARK
		STATE:			NJ
		ZIP:			07102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PRAMERICA ALPHA FIXED INCOME OPPORTUNITY FUND (CAYMAN) SPC LTD
		DATE OF NAME CHANGE:	20080319
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001430172</cik>
        <entityName>PRAMERICA ALPHA FIXED INCOME OPPORTUNITY FUND (CAYMAN) SPC, LTD.</entityName>
        <issuerAddress>
            <street1>Prudential Investment Management, Inc.</street1>
            <street2>Two Gateway Center, Third Floor</street2>
            <city>Newark</city>
            <stateOrCountry>NJ</stateOrCountry>
            <zipCode>07102</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>973-802-5702</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <issuerPreviousNameList></issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>PRAMERICA ALPHA FIXED INCOME OPPORTUNITY FUND (CAYMAN) SPC LTD</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Steven</firstName>
                <middleName>B.</middleName>
                <lastName>Saperstein</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Prudential Investment Management, Inc.</street1>
                <street2>Two Gateway Center, Third Floor</street2>
                <city>Newark</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07102</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <lastName>Cordrey</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Prudential Investment Management, Inc.</street1>
                <street2>Two Gateway Center, Third Floor</street2>
                <city>Newark</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07102</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>n/a</firstName>
                <lastName>Prudential Investment Management, Inc.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Gateway Center, Third Floor</street1>
                <city>Newark</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>07102</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-09-013723</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-03-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Participating redeemable shares, par value $0.01, in Pramerica S&amp;P 500 Beta Overlay Segregated Portfolio of Pramerica Alpha Fixed Income Opportunity Fund (Cayman) SPC, Ltd.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>100000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Not Applicable</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>Prudential Investment Management Services LLC</associatedBDName>
                <associatedBDCRDNumber>18353</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Three Gateway Center, 14th Floor</street1>
                    <city>Newark</city>
                    <stateOrCountry>NJ</stateOrCountry>
                    <zipCode>07102-4077</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>75000000</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>The Issuer does not bear the expense of any commissions or fees with respect  to the services of Prudential Investment Management Services LLC.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>Prudential Investment Management, Inc. is entitled to receive fees as investment manager of the Issuer.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Pramerica Alpha Fixed Income Opportunity Fund (Cayman) SPC, Ltd.</issuerName>
                <signatureName>/s/ Peter Cordrey</signatureName>
                <nameOfSigner>Peter Cordrey</nameOfSigner>
                <signatureTitle>Director</signatureTitle>
                <signatureDate>2010-03-08</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
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