-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001427925-10-000001.txt : 20100921
<SEC-HEADER>0001427925-10-000001.hdr.sgml : 20100921
<ACCEPTANCE-DATETIME>20100920181934
ACCESSION NUMBER:		0001427925-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100921
DATE AS OF CHANGE:		20100920
EFFECTIVENESS DATE:		20100921

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ACELRX PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001427925
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-147977
		FILM NUMBER:		101081276

	BUSINESS ADDRESS:	
		STREET 1:		575 CHESAPEAKE DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		650-216-3500

	MAIL ADDRESS:	
		STREET 1:		575 CHESAPEAKE DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <primaryIssuer>
        <cik>0001427925</cik>
        <entityName>ACELRX PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>575 CHESAPEAKE DRIVE</street1>
            <city>REDWOOD CITY</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>94063</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>650-216-3500</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Surx, Inc.</previousName>
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        <entityType>Corporation</entityType>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <lastName>King</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Pamela</firstName>
                <lastName>Palmer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Carter</firstName>
                <lastName>King</lastName>
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            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
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                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
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                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Larry</firstName>
                <lastName>Hamel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
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                <firstName>Anil</firstName>
                <lastName>Dasu</lastName>
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            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Linda</firstName>
                <lastName>Judge</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Howie</firstName>
                <lastName>Rosen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Guy</firstName>
                <lastName>Nohra</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Alta Partners</street1>
                <street2>One Embarcadero Center, 37th Floor</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94111</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <lastName>Hoffman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Skyline Venture Partners</street1>
                <street2>525 University Avenue, #520</street2>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <lastName>Wan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Three Arch Partners</street1>
                <street2>3200 Alpine Road</street2>
                <city>Portola Valley</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94028</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Schreck</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o AcelRx Pharmaceuticals, Inc.</street1>
                <street2>575 Chesapeake Drive</street2>
                <city>Redwood City</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-09-14</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>12001200</totalOfferingAmount>
            <totalAmountSold>8000800</totalAmountSold>
            <totalRemaining>4000400</totalRemaining>
            <clarificationOfResponse>Promissory Notes convertible into Preferred Stock; Warrants to purchase Preferred Stock</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>8</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>The proceeds will be used for general corporate purposes.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ACELRX PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ Mark B. Weeks</signatureName>
                <nameOfSigner>Mark B. Weeks</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2010-09-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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