-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 SZZ9RJS0k0zYWj2eLH47/Q==

<SEC-DOCUMENT>0001426332-10-000001.txt : 20100405
<SEC-HEADER>0001426332-10-000001.hdr.sgml : 20100405
<ACCEPTANCE-DATETIME>20100405172226
ACCESSION NUMBER:		0001426332-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100405
DATE AS OF CHANGE:		20100405
EFFECTIVENESS DATE:		20100405

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NGM BIOPHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001426332
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-114428
		FILM NUMBER:		10732261

	BUSINESS ADDRESS:	
		STREET 1:		2855 CHURCHILL DR
		CITY:			HILLSBOROUGH
		STATE:			CA
		ZIP:			94010
		BUSINESS PHONE:		650-685-6655

	MAIL ADDRESS:	
		STREET 1:		2855 CHURCHILL DR
		CITY:			HILLSBOROUGH
		STATE:			CA
		ZIP:			94010
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001426332</cik>
        <entityName>NGM BIOPHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>630 Gateway Boulevard</street1>
            <city>South San Francisco</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94080</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>650-243-5555</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2007</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jin-Long</firstName>
                <lastName>Chen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NGM Biopharmaceuticals, Inc.</street1>
                <street2>630 Gateway Boulevard</street2>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Luis</firstName>
                <lastName>Bayol</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NGM Biopharmaceuticals, Inc.</street1>
                <street2>630 Gateway Boulevard</street2>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>V.</middleName>
                <lastName>Goeddel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NGM Biopharmaceuticals, Inc.</street1>
                <street2>630 Gateway Boulevard</street2>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Helen</firstName>
                <lastName>Kim</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NGM Biopharmaceuticals, Inc.</street1>
                <street2>630 Gateway Boulevard</street2>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marc</firstName>
                <lastName>Leschly</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Rho Ventures</street1>
                <street2>525 University Ave., Suite 1350</street2>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Arthur</firstName>
                <middleName>D.</middleName>
                <lastName>Levinson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o NGM Biopharmaceuticals, Inc.</street1>
                <street2>630 Gateway Boulevard</street2>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Schnell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Prospect Ventures, L.P.</street1>
                <street2>435 Tasso St., Suite 200</street2>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <lastName>Svennilson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3121 Polo Drive</street1>
                <city>Gulf Stream</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33483</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>McHenry</firstName>
                <middleName>T.</middleName>
                <lastName>Tichenor, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Tichenor Ventures, LLC</street1>
                <street2>100 Crescent Court, Suite 700</street2>
                <city>Dallas</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75201</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-10</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Sale and issuance of Series B preferrred stock and the underlying shares of common stock issuable upon conversion thereof.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>51139000</totalOfferingAmount>
            <totalAmountSold>17029670</totalAmountSold>
            <totalRemaining>34109330</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>19</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>NGM BIOPHARMACEUTICALS INC</issuerName>
                <signatureName>Michael E. Tenta</signatureName>
                <nameOfSigner>Michael E. Tenta</nameOfSigner>
                <signatureTitle>Assistant Secretary</signatureTitle>
                <signatureDate>2010-03-30</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----