-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 ZdZ7qSgrxOqvrFxn88nRfQ==

<SEC-DOCUMENT>0001144204-11-012960.txt : 20110304
<SEC-HEADER>0001144204-11-012960.hdr.sgml : 20110304
<ACCEPTANCE-DATETIME>20110304163306
ACCESSION NUMBER:		0001144204-11-012960
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20110304
DATE AS OF CHANGE:		20110304
EFFECTIVENESS DATE:		20110304

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENSPERA INC
		CENTRAL INDEX KEY:			0001421204
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-155334
		FILM NUMBER:		11665082

	BUSINESS ADDRESS:	
		STREET 1:		2511 N LOOP 1604 W
		STREET 2:		SUITE 204
		CITY:			SAN ANTONIO
		STATE:			TX
		ZIP:			78258
		BUSINESS PHONE:		(210) 479-8112

	MAIL ADDRESS:	
		STREET 1:		2511 N LOOP 1604 W
		STREET 2:		SUITE 204
		CITY:			SAN ANTONIO
		STATE:			TX
		ZIP:			78258
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001421204</cik>
        <entityName>GENSPERA INC</entityName>
        <issuerAddress>
            <street1>2511 N Loop 1604 W</street1>
            <city>San Antonio</city>
            <stateOrCountry>TX</stateOrCountry>
            <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
            <zipCode>78258</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(210) 479-8112</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Craig</firstName>
                <lastName>Dionne</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2511 N Loop 1604 W</street1>
                <street2>Suite 204</street2>
                <city>San Antonio</city>
                <stateOrCountry>TX</stateOrCountry>
                <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
                <zipCode>78258</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Russell</firstName>
                <lastName>Richerson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2511 N Loop 1604 W</street1>
                <street2>Suite 204</street2>
                <city>San Antonio</city>
                <stateOrCountry>TX</stateOrCountry>
                <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
                <zipCode>78258</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Scott</firstName>
                <middleName>V.</middleName>
                <lastName>Ogilvie</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2511 N Loop 1604 W</street1>
                <street2>Suite 204</street2>
                <city>San Antonio</city>
                <stateOrCountry>TX</stateOrCountry>
                <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
                <zipCode>78258</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bo</firstName>
                <middleName>Jesper</middleName>
                <lastName>Hansen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2511 N Loop 1604 W</street1>
                <street2>Suite 204</street2>
                <city>San Antonio</city>
                <stateOrCountry>TX</stateOrCountry>
                <stateOrCountryDescription>TEXAS</stateOrCountryDescription>
                <zipCode>78258</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001144204-11-008703</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2011-01-21</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Unit Offering: (i) one (1) share of common, and (ii) one half (1/2) common stock purchase warrant.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>15000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Galt Financial Group Inc.</recipientName>
                <recipientCRDNumber>146976</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>2815 Townsgate Road</street1>
                    <street2>Suite 100</street2>
                    <city>Westlake Village</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                    <zipCode>91361</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Walter H. Bass, LLC</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>P.O. Box 3040</street1>
                    <city>Anaheim</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                    <zipCode>92803</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5000000</totalOfferingAmount>
            <totalAmountSold>4034883</totalAmountSold>
            <totalRemaining>965117</totalRemaining>
            <clarificationOfResponse>The offering is now complete.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>22</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>10003</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>110695</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>490000</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Represents approximate annual salaries of our named executive officers, directors and promotors</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>true</authorizedRepresentative>
            <signature>
                <issuerName>GENSPERA INC</issuerName>
                <signatureName>/s/ Craig Dionne</signatureName>
                <nameOfSigner>Craig Dionne</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2011-03-03</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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