-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 M2f6GlpK+7edVc9q1gu2qGIGqw3ZiyRvHc66aZGtx/g1ObX6IJxPrTIXJ+sw572k
 KO61Xmy0D2lQYcUrABgJNg==

<SEC-DOCUMENT>0001417827-09-000005.txt : 20090527
<SEC-HEADER>0001417827-09-000005.hdr.sgml : 20090527
<ACCEPTANCE-DATETIME>20090527120257
ACCESSION NUMBER:		0001417827-09-000005
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090527
DATE AS OF CHANGE:		20090527
EFFECTIVENESS DATE:		20090527

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Miragen Therapeutics Inc
		CENTRAL INDEX KEY:			0001417827
		IRS NUMBER:				204362468
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-110805
		FILM NUMBER:		09853790

	BUSINESS ADDRESS:	
		STREET 1:		6200 LOOKOUT ROAD
		CITY:			Boulder
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		(303) 531-5952

	MAIL ADDRESS:	
		STREET 1:		6200 LOOKOUT ROAD
		CITY:			Boulder
		STATE:			CO
		ZIP:			80301
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001417827</cik>
        <entityName>Miragen Therapeutics Inc</entityName>
        <issuerAddress>
            <street1>6200 LOOKOUT ROAD</street1>
            <street2></street2>
            <city>Boulder</city>
            <stateOrCountry>CO</stateOrCountry>
            <zipCode>80301</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(303) 531-5952</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>358th Shelf Corporation</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2006</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>S.</middleName>
                <lastName>Marshall</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6200 Lookout Road</street1>
                <street2></street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marvin</firstName>
                <middleName></middleName>
                <lastName>Caruthers</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6200 Lookout Road</street1>
                <street2></street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kyle</firstName>
                <middleName></middleName>
                <lastName>Lefkoff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6200 Lookout Road</street1>
                <street2></street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bruce</firstName>
                <middleName></middleName>
                <lastName>Booth</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6200 Lookout Road</street1>
                <street2></street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-08-030784</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-05-16</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>11999997</totalOfferingAmount>
            <totalAmountSold>11999997</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>28</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Miragen Therapeutics Inc</issuerName>
                <signatureName>William S. Marshall</signatureName>
                <nameOfSigner>William S. Marshall</nameOfSigner>
                <signatureTitle>President &amp; CEO</signatureTitle>
                <signatureDate>2009-05-27</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----