-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 WMokuS2mx0bSSEkpvz2d2qr8zVWc81Q+yVm/9HqPoE7huJqzs38nYsi6zYaCOLsT
 /5xxbx6Li8tFfhH1ul5GaQ==

<SEC-DOCUMENT>0001400820-09-000004.txt : 20090805
<SEC-HEADER>0001400820-09-000004.hdr.sgml : 20090805
<ACCEPTANCE-DATETIME>20090804182710
ACCESSION NUMBER:		0001400820-09-000004
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090805
DATE AS OF CHANGE:		20090804
EFFECTIVENESS DATE:		20090805

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NanoH2O, Inc.
		CENTRAL INDEX KEY:			0001400820
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-103537
		FILM NUMBER:		09985029

	BUSINESS ADDRESS:	
		STREET 1:		570 WESTWOOD PLAZA, SUITE 6532
		STREET 2:		BUILDING 114, MC 722710
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90095-7277
		BUSINESS PHONE:		310-717-1018

	MAIL ADDRESS:	
		STREET 1:		570 WESTWOOD PLAZA, SUITE 6532
		STREET 2:		BUILDING 114, MC 722710
		CITY:			LOS ANGELES
		STATE:			CA
		ZIP:			90095-7277
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001400820</cik>
        <entityName>NanoH2O, Inc.</entityName>
        <issuerAddress>
            <street1>570 WESTWOOD PLAZA, SUITE 6532</street1>
            <street2>BUILDING 114, MC 722710</street2>
            <city>LOS ANGELES</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>90095-7277</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>310-717-1018</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2005</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeffrey</firstName>
                <middleName></middleName>
                <lastName>Green</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>570 Westwood Plaza, Suite 6532</street1>
                <street2>Building 114, MC 722710</street2>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90095</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName></middleName>
                <lastName>McDermott</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Rusheen Capital Partners, LLC</street1>
                <street2>2332 Mandeville Canyon Road</street2>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90049</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Samir</firstName>
                <middleName></middleName>
                <lastName>Kaul</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Khosla Ventures, 3000 Sand Hill Road</street1>
                <street2>Building 3, Suite 170</street2>
                <city>Menlo Park</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94025</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <middleName></middleName>
                <lastName>Hinman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Oak Investment Partners, LP</street1>
                <street2>525 University Avenue, Suite 1300</street2>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gilad</firstName>
                <middleName></middleName>
                <lastName>Almogy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>881 Northhampton Drive</street1>
                <street2></street2>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94303</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>CJ</firstName>
                <middleName></middleName>
                <lastName>Kurth</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>570 Westwood Plaza, Suite 6532</street1>
                <street2>Building 114, MC 722710</street2>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90095</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bob</firstName>
                <middleName></middleName>
                <lastName>Burk</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>570 Westwood Plaza, Suite 6532</street1>
                <street2>Building 114, MC 722710</street2>
                <city>Los Angeles</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90095</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Environmental Services</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-08-04</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>4999997</totalOfferingAmount>
            <totalAmountSold>4999997</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>2</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>NanoH2O, Inc.</issuerName>
                <signatureName>Jeffrey Green</signatureName>
                <nameOfSigner>Jeffrey Green</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2009-08-04</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----