-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 7BNfX9FPrUCT+CByakZyoQ==

<SEC-DOCUMENT>0001395387-09-000003.txt : 20090423
<SEC-HEADER>0001395387-09-000003.hdr.sgml : 20090423
<ACCEPTANCE-DATETIME>20090422212812
ACCESSION NUMBER:		0001395387-09-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090423
DATE AS OF CHANGE:		20090422
EFFECTIVENESS DATE:		20090423

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORAYA THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001395387
		IRS NUMBER:				205114559
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-101715
		FILM NUMBER:		09764852

	BUSINESS ADDRESS:	
		STREET 1:		8000 JARVIS AVENUE
		CITY:			NEWARK
		STATE:			CA
		ZIP:			94560
		BUSINESS PHONE:		5104563702

	MAIL ADDRESS:	
		STREET 1:		8000 JARVIS AVENUE
		CITY:			NEWARK
		STATE:			CA
		ZIP:			94560
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001395387</cik>
        <entityName>ORAYA THERAPEUTICS INC</entityName>
        <issuerAddress>
            <street1>8000 JARVIS AVENUE</street1>
            <street2></street2>
            <city>NEWARK</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94560</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>5104563702</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2006</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName></middleName>
                <lastName>Gertner</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8000 Jarvis Avenue</street1>
                <street2>Building 5</street2>
                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94560</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Guido</firstName>
                <middleName></middleName>
                <lastName>Neels</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8000 Jarvis Avenue</street1>
                <street2>Building 5</street2>
                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94560</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName></middleName>
                <lastName>Onopchenko</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8000 Jarvis Avenue</street1>
                <street2>Building 5</street2>
                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94560</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Reza</firstName>
                <middleName></middleName>
                <lastName>Zadno</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8000 Jarvis Avenue</street1>
                <street2>Building 5</street2>
                <city>Newark</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94560</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName></middleName>
                <lastName>Cohn</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1020 Marsh Road</street1>
                <street2></street2>
                <city>Menlo Park</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94025</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Technology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-04-03</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Subordinated Convertible Promissory Notes and Preferred Stock Warrants</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>6000060</totalOfferingAmount>
            <totalAmountSold>3000030</totalAmountSold>
            <totalRemaining>3000030</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>2</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ORAYA THERAPEUTICS INC</issuerName>
                <signatureName>Peter Cohn</signatureName>
                <nameOfSigner>Peter Cohn</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2009-04-22</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----