-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001382090-09-000004.txt : 20091030
<SEC-HEADER>0001382090-09-000004.hdr.sgml : 20091030
<ACCEPTANCE-DATETIME>20091030150318
ACCESSION NUMBER:		0001382090-09-000004
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091030
DATE AS OF CHANGE:		20091030
EFFECTIVENESS DATE:		20091030

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cequent Pharmaceuticals Inc
		CENTRAL INDEX KEY:			0001382090
		IRS NUMBER:				562413195
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-96942
		FILM NUMBER:		091147818

	BUSINESS ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		STREET 2:		BUILDING 700, FIRST FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-995-7940

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		STREET 2:		BUILDING 700, FIRST FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001382090</cik>
        <entityName>Cequent Pharmaceuticals Inc</entityName>
        <issuerAddress>
            <street1>ONE KENDALL SQUARE</street1>
            <street2>BUILDING 700, FIRST FLOOR</street2>
            <city>CAMBRIDGE</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>02139</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>617-995-7940</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Cequent, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName>D.</middleName>
                <lastName>Parker</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Kendall Square</street1>
                <street2>Building 700, First Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Chiang</firstName>
                <lastName>Li</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Kendall Square</street1>
                <street2>Building 700, First Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Herbert</firstName>
                <middleName>H.</middleName>
                <lastName>Hooper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Ampersand Ventures</street1>
                <street2>55 William Street, Suite 240</street2>
                <city>Wellesley</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02481</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eric</firstName>
                <lastName>Linsley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>A.M. Pappas Life Science Ventures III LP</street1>
                <street2>2520 Meridian Parkway, Suite 400</street2>
                <city>Durham</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Lauren</firstName>
                <lastName>Silverman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Kendall Square</street1>
                <street2>Building 700, First Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Taylor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Ensemble Discovery</street1>
                <street2>99 Erie Street</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Hancock</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>New England Partners Capital, L.P.</street1>
                <street2>One Boston Place, Suite 3630</street2>
                <city>Boston</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-10-16</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>10843435</totalOfferingAmount>
            <totalAmountSold>2653536</totalAmountSold>
            <totalRemaining>8189899</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Cequent Pharmaceuticals Inc</issuerName>
                <signatureName>/s/ Peter D. Parker</signatureName>
                <nameOfSigner>Peter D. Parker</nameOfSigner>
                <signatureTitle>President</signatureTitle>
                <signatureDate>2009-10-30</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----