-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001382014-10-000002.txt : 20100730
<SEC-HEADER>0001382014-10-000002.hdr.sgml : 20100730
<ACCEPTANCE-DATETIME>20100729183648
ACCESSION NUMBER:		0001382014-10-000002
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100730
DATE AS OF CHANGE:		20100729
EFFECTIVENESS DATE:		20100730

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CARDIOXYL PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001382014
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-145689
		FILM NUMBER:		10979088

	BUSINESS ADDRESS:	
		STREET 1:		1450 RALEIGH ROAD
		STREET 2:		EXCHANGE EAST, SUITE 212
		CITY:			CHAPEL HILL
		STATE:			NC
		ZIP:			27517
		BUSINESS PHONE:		(919) 869-8585

	MAIL ADDRESS:	
		STREET 1:		1450 RALEIGH ROAD
		STREET 2:		EXCHANGE EAST, SUITE 212
		CITY:			CHAPEL HILL
		STATE:			NC
		ZIP:			27517
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001382014</cik>
        <entityName>CARDIOXYL PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>1450 RALEIGH ROAD</street1>
            <street2>EXCHANGE EAST, SUITE 212</street2>
            <city>CHAPEL HILL</city>
            <stateOrCountry>NC</stateOrCountry>
            <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
            <zipCode>27517</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(919) 869-8585</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2005</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <middleName>A.</middleName>
                <lastName>Kroeger</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Cardioxyl Pharmaceuticals, Inc.</street1>
                <street2>1450 Raleigh Road,Exchange East, Ste 212</street2>
                <city>Chapel Hill</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27517</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Reza</firstName>
                <lastName>Mazhari</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Cardioxyl Pharmaceuticals, Inc.</street1>
                <street2>1450 Raleigh Road,Exchange East,Ste 212</street2>
                <city>Chapel Hill</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27517</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Barrett</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o New Enterprise Associates</street1>
                <street2>5425 Wisconsin Avenue, Suite 800</street2>
                <city>Chevy Chase</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20815</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeff</firstName>
                <lastName>Clark</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o The Aurora Funds, Inc.</street1>
                <street2>2525 Meridian Parkway, Suite 200</street2>
                <city>Durham</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27713</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Garland</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o New Enterprise Associates</street1>
                <street2>2855 Sand Hill Road</street2>
                <city>Menlo Park</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94025</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Charles</firstName>
                <lastName>Sanders</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Cardioxyl Pharmaceuticals, Inc.</street1>
                <street2>1450 Raleigh Road,Exchange East, Ste 212</street2>
                <city>Chapel Hill</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27517</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Doug</firstName>
                <lastName>Cowart</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Cardioxyl Pharmaceuticals, Inc.</street1>
                <street2>1450 Raleigh Road,Exchange East, Ste 212</street2>
                <city>Chapel Hill</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27517</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Reardon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Cardioxyl Pharmaceuticals, Inc.</street1>
                <street2>1450 Raleigh Road,Exchange East, Ste 212</street2>
                <city>Chapel Hill</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27517</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Vince</firstName>
                <lastName>Kalish</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Cardioxyl Pharmaceuticals, Inc.</street1>
                <street2>1450 Raleigh Road,Exchange East, Ste 212</street2>
                <city>Chapel Hill</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27517</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-07-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>15000000</totalOfferingAmount>
            <totalAmountSold>15000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>2</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CARDIOXYL PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ Christopher A. Kroeger</signatureName>
                <nameOfSigner>Christopher A. Kroeger</nameOfSigner>
                <signatureTitle>Chief Executive Officer and President</signatureTitle>
                <signatureDate>2010-07-29</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----