-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001140361-09-029853.txt : 20091221
<SEC-HEADER>0001140361-09-029853.hdr.sgml : 20091221
<ACCEPTANCE-DATETIME>20091221161637
ACCESSION NUMBER:		0001140361-09-029853
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091221
DATE AS OF CHANGE:		20091221
EFFECTIVENESS DATE:		20091221

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EYEGATE PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001372514
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-93705
		FILM NUMBER:		091252553

	BUSINESS ADDRESS:	
		STREET 1:		100 BEAVER STREET
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453
		BUSINESS PHONE:		781-788-9043

	MAIL ADDRESS:	
		STREET 1:		100 BEAVER STREET
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001372514</cik>
        <entityName>EYEGATE PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>100 BEAVER STREET</street1>
            <city>WALTHAM</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>02453</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>781-788-9043</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <lastName>From</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Eyegate Pharmaceuticals, Inc.</street1>
                <street2>100 Beaver Street</street2>
                <city>Waltham</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02453</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J.</firstName>
                <middleName>Sebastien</middleName>
                <lastName>Cleftie</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Innoven Partnenaires</street1>
                <street2>10, rue de la Paix</street2>
                <city>Paris</city>
                <stateOrCountry>I0</stateOrCountry>
                <zipCode>75002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alain</firstName>
                <lastName>Maiore</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Ventech</street1>
                <street2>5-7 rue de Monttessuy</street2>
                <city>Paris</city>
                <stateOrCountry>I0</stateOrCountry>
                <zipCode>75340</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Mullen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>97 Wolf Pond Rd</street1>
                <city>Kingston</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02364</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>E.</middleName>
                <lastName>Hancock</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o New England Partners Capital, L.P.</street1>
                <street2>400 Crown Colony Drive, Suite 104</street2>
                <city>Quincy</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02169</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <lastName>Chaney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o OSI Pharmaceuticals, Inc.</street1>
                <street2>41 Pinelawn Rd</street2>
                <city>Melville</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>11747</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Morton</firstName>
                <lastName>Goldberg</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Eyegate Pharmaceuticals, Inc.</street1>
                <street2>100 Beaver Street</street2>
                <city>Waltham</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02453</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Praveen</firstName>
                <lastName>Tyle</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Eyegate Pharmaceuticals, Inc.</street1>
                <street2>100 Beaver Street</street2>
                <city>Waltham</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02453</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-12-08</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>1</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>22641695</totalOfferingAmount>
            <totalAmountSold>11081232</totalAmountSold>
            <totalRemaining>11560463</totalRemaining>
            <clarificationOfResponse>Amount includes investments made by foreign entities.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>20</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>EYEGATE PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ Stephen From</signatureName>
                <nameOfSigner>Stephen From</nameOfSigner>
                <signatureTitle>President</signatureTitle>
                <signatureDate>2009-12-21</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----