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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001369655-08-000003.txt : 20081218
<SEC-HEADER>0001369655-08-000003.hdr.sgml : 20081218
<ACCEPTANCE-DATETIME>20081218132232
ACCESSION NUMBER:		0001369655-08-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20081218
DATE AS OF CHANGE:		20081218
EFFECTIVENESS DATE:		20081218

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Osmetech PLC
		CENTRAL INDEX KEY:			0001369655
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-92048
		FILM NUMBER:		081257025

	BUSINESS ADDRESS:	
		STREET 1:		1 Liverpool Street
		CITY:			London
		STATE:			X0
		ZIP:			00000
		BUSINESS PHONE:		44-7810-014-810

	MAIL ADDRESS:	
		STREET 1:		1 Liverpool Street
		CITY:			London
		STATE:			X0
		ZIP:			00000
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0201</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001369655</cik>
        <entityName>Osmetech PLC</entityName>
        <issuerAddress>
            <street1>c/o Osmetech Inc.</street1>
            <street2>757 S. Raymond Avenue</street2>
            <city>Pasadena</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>91105</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>626-463-2000</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>X0</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gordon</firstName>
                <middleName>James</middleName>
                <lastName>Hall</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Broadwalk House</street1>
                <street2>5 Appold Street</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <zipCode>EC2A 2HA</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>Anthony</middleName>
                <lastName>Sandilands</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Broadwalk House</street1>
                <street2>5 Appold Street</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <zipCode>EC2A 2HA</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>Nicholas Gerald</middleName>
                <lastName>White</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Broadwalk House</street1>
                <street2>5 Appold Street</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <zipCode>EC2A 2HA</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gordon</firstName>
                <middleName>Bruce</middleName>
                <lastName>Kuenstor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Broadwalk House</street1>
                <street2>5 Appold Street</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <zipCode>EC2A 2HA</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Daryl</firstName>
                <middleName>J</middleName>
                <lastName>Faulkner</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Broadwalk House</street1>
                <street2>5 Appold Street</street2>
                <city>London</city>
                <stateOrCountry>X0</stateOrCountry>
                <zipCode>EC2A 2HA</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-12-04</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5000000</totalOfferingAmount>
            <totalAmountSold>5000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>2</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>true</authorizedRepresentative>
            <signature>
                <issuerName>Osmetech PLC</issuerName>
                <signatureName>Sally Craig</signatureName>
                <nameOfSigner>Sally Craig</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2008-12-18</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----