-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 HoqNBnh4G3ttJ52ySEJ72F9cAKBffWtvOQMCmseetKEjeRk6Sqv+Iei0nByZU0vp
 17y2UhhlzKrL6za388d7TQ==

<SEC-DOCUMENT>0001365916-10-000002.txt : 20100402
<SEC-HEADER>0001365916-10-000002.hdr.sgml : 20100402
<ACCEPTANCE-DATETIME>20100402153418
ACCESSION NUMBER:		0001365916-10-000002
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100402
DATE AS OF CHANGE:		20100402
EFFECTIVENESS DATE:		20100402

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AMYRIS BIOTECHNOLOGIES INC
		CENTRAL INDEX KEY:			0001365916
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-90769
		FILM NUMBER:		10728218

	BUSINESS ADDRESS:	
		STREET 1:		5980 HORTON ST SUITE 450
		CITY:			EMERYVILLE
		STATE:			CA
		ZIP:			94608
		BUSINESS PHONE:		510-450-0761

	MAIL ADDRESS:	
		STREET 1:		5980 HORTON ST SUITE 450
		CITY:			EMERYVILLE
		STATE:			CA
		ZIP:			94608
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <cik>0001365916</cik>
        <entityName>AMYRIS BIOTECHNOLOGIES INC</entityName>
        <issuerAddress>
            <street1>5885 HOLLIS ST., SUITE 100</street1>
            <city>EMERYVILLE</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94608</zipCode>
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        <issuerPhoneNumber>510-450-0761</issuerPhoneNumber>
        <jurisdictionOfInc>CALIFORNIA</jurisdictionOfInc>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Melo</lastName>
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            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jack</firstName>
                <lastName>Newman</lastName>
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            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kinkead</firstName>
                <lastName>Reiling</lastName>
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            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Neil</firstName>
                <lastName>Renninger</lastName>
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                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeryl</firstName>
                <lastName>Hilleman</lastName>
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            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tamara</firstName>
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            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeff</firstName>
                <lastName>Lievense</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joel</firstName>
                <lastName>Cherry</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Fernando</firstName>
                <lastName>Reinach</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ralph</firstName>
                <lastName>Alexander</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Doerr</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Geoff</firstName>
                <lastName>Duyk</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Samir</firstName>
                <lastName>Kaul</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Carole</firstName>
                <lastName>Piwnica</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5885 Hollis St., Suite 100</street1>
                <city>Emeryville</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94608</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-19</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>47846891</totalOfferingAmount>
            <totalAmountSold>47846891</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>AMYRIS BIOTECHNOLOGIES INC</issuerName>
                <signatureName>/s/ Tamara Tompkins</signatureName>
                <nameOfSigner>Tamara Tompkins</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2010-03-30</signatureDate>
            </signature>
        </signatureBlock>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----