-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 NII5+IXwBs+bLY0/yZGC+w==

<SEC-DOCUMENT>0001358762-10-000001.txt : 20100226
<SEC-HEADER>0001358762-10-000001.hdr.sgml : 20100226
<ACCEPTANCE-DATETIME>20100226153427
ACCESSION NUMBER:		0001358762-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100226
DATE AS OF CHANGE:		20100226
EFFECTIVENESS DATE:		20100226

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			REATA PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001358762
		IRS NUMBER:				113651945
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-88081
		FILM NUMBER:		10638902

	BUSINESS ADDRESS:	
		STREET 1:		2801 GATEWAY DRIVE SUITE 150
		CITY:			IRVING
		STATE:			TX
		ZIP:			75063
		BUSINESS PHONE:		972-865-2206

	MAIL ADDRESS:	
		STREET 1:		2801 GATEWAY DRIVE SUITE 150
		CITY:			IRVING
		STATE:			TX
		ZIP:			75063
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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<edgarSubmission>

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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

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        <cik>0001358762</cik>
        <entityName>REATA PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>2801 GATEWAY DRIVE SUITE 150</street1>
            <city>IRVING</city>
            <stateOrCountry>TX</stateOrCountry>
            <zipCode>75063</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>972-865-2201</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Reata Discovery, Inc.</previousName>
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        <entityType>Corporation</entityType>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J.</firstName>
                <middleName>Warren</middleName>
                <lastName>Huff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1002 Ashlawn Drive</street1>
                <city>Southlake</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>76092</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jack</firstName>
                <middleName>B.</middleName>
                <lastName>Nielsen</lastName>
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            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
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            <relatedPersonName>
                <firstName>Dennis</firstName>
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                <street1>5323 Harry Hines Boulevard</street1>
                <street2>McDermott Admin. Bldg, Room B12.200</street2>
                <city>Dallas</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75390</zipCode>
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            <relatedPersonRelationshipList>
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                <city>Dallas</city>
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                <firstName>Jason</firstName>
                <middleName>D.</middleName>
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                <city>Irving</city>
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            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>Christian</middleName>
                <lastName>Wigley</lastName>
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                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eric</firstName>
                <lastName>Grossman</lastName>
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            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kent</firstName>
                <lastName>McGaughy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 McKinney, Suite 1770</street1>
                <city>Dallas</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75201</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Edward</firstName>
                <middleName>W.</middleName>
                <lastName>Rose</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 McKinney, Suite 1770</street1>
                <city>Dallas</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75201</zipCode>
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            <relatedPersonRelationshipList>
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            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Charles</firstName>
                <middleName>A.</middleName>
                <lastName>Sanders</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Colin</firstName>
                <lastName>Meyer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Melissa</firstName>
                <lastName>Krauth</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>M.</middleName>
                <lastName>Kral, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Walling</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Melean</firstName>
                <lastName>Visnick</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2801 Gateway Drive, Suite 150</street1>
                <city>Irving</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>75063</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-02-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1972000</totalOfferingAmount>
            <totalAmountSold>1972000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
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            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>REATA PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ J. Warren Huff</signatureName>
                <nameOfSigner>J. Warren Huff</nameOfSigner>
                <signatureTitle>Chief Executive Officer and President</signatureTitle>
                <signatureDate>2010-02-26</signatureDate>
            </signature>
        </signatureBlock>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----