-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 T6DR1ueGtJi3ygDBpkPHdbfboMUy/JlcuFVQAnV0I77t7AJkhJ1ohxWY0Ut7iTR/
 FyMGFVAUtDL9OBj5yMR3YA==

<SEC-DOCUMENT>0001209191-09-049855.txt : 20091027
<SEC-HEADER>0001209191-09-049855.hdr.sgml : 20091027
<ACCEPTANCE-DATETIME>20091027134905
ACCESSION NUMBER:		0001209191-09-049855
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091027
DATE AS OF CHANGE:		20091027
EFFECTIVENESS DATE:		20091027

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sirion Holdings, Inc.
		CENTRAL INDEX KEY:			0001355015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-95293
		FILM NUMBER:		091138789

	BUSINESS ADDRESS:	
		STREET 1:		3110 CHERRY PALM DRIVE
		STREET 2:		SUITE 340
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33619
		BUSINESS PHONE:		813 496 7325

	MAIL ADDRESS:	
		STREET 1:		3110 CHERRY PALM DRIVE
		STREET 2:		SUITE 340
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33619

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TENBY PHARMA INC
		DATE OF NAME CHANGE:	20060303
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001355015</cik>
        <entityName>Sirion Holdings, Inc.</entityName>
        <issuerAddress>
            <street1>9314 East Broadway Avenue</street1>
            <city>Tampa</city>
            <stateOrCountry>FL</stateOrCountry>
            <zipCode>33619</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(813) 496-7325</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Tenby Pharma, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>TENBY PHARMA INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2006</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Barry</firstName>
                <lastName>Butler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Charles</firstName>
                <lastName>Cohen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrew</firstName>
                <lastName>Schiff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Riedhammer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <lastName>Barrett</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kevin</firstName>
                <lastName>Kinsella</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Liza Page</firstName>
                <lastName>Nelson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Susan</firstName>
                <lastName>Benton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Todd</firstName>
                <lastName>Creech</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Roger</firstName>
                <lastName>Vogel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Sirion Holdings, Inc.</street1>
                <street2>9314 East Broadway Avenue</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33619</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-10-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>66693609</totalOfferingAmount>
            <totalAmountSold>27684009</totalAmountSold>
            <totalRemaining>39009600</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>17</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Sirion Holdings, Inc.</issuerName>
                <signatureName>/s/ Todd Creech</signatureName>
                <nameOfSigner>Todd Creech</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-10-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----