-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 T4gGn8EWNHEbH66RldH0Wg==

<SEC-DOCUMENT>0000898432-10-000025.txt : 20100113
<SEC-HEADER>0000898432-10-000025.hdr.sgml : 20100113
<ACCEPTANCE-DATETIME>20100113144122
ACCESSION NUMBER:		0000898432-10-000025
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100113
DATE AS OF CHANGE:		20100113
EFFECTIVENESS DATE:		20100113

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Knopp Neurosciences Inc.
		CENTRAL INDEX KEY:			0001347819
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-84369
		FILM NUMBER:		10524865

	BUSINESS ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 615
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203
		BUSINESS PHONE:		412-488-1776

	MAIL ADDRESS:	
		STREET 1:		2100 WHARTON STREET
		STREET 2:		SUITE 615
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Knopp NeuroSciences Inc
		DATE OF NAME CHANGE:	20051222
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001347819</cik>
        <entityName>Knopp Neurosciences Inc.</entityName>
        <issuerAddress>
            <street1>2100 Wharton Street</street1>
            <street2>Suite 615</street2>
            <city>Pittsburgh</city>
            <stateOrCountry>PA</stateOrCountry>
            <zipCode>15203</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>412-488-1776</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Knopp Neurosciences Merger Sub, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Knopp NeuroSciences Inc</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2006</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>E.</middleName>
                <lastName>Bozik</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 Wharton Street</street1>
                <street2>Suite 615</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gregory</firstName>
                <middleName>T.</middleName>
                <lastName>Hebrank</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 Wharton Street</street1>
                <street2>Suite 615</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas, Jr.</firstName>
                <lastName>Petzinger</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 Wharton Street</street1>
                <street2>Suite 615</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Evan</firstName>
                <lastName>Ingersoll</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 Wharton Street</street1>
                <street2>Suite 615</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Valentin</firstName>
                <middleName>K.</middleName>
                <lastName>Gribkoff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2100 Wharton Street</street1>
                <street2>Suite 615</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeffrey</firstName>
                <middleName>S.</middleName>
                <lastName>McCormick</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Saturn Management LLC</street1>
                <street2>75 Federal Street</street2>
                <city>Boston</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02110</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ben</firstName>
                <lastName>Gomez</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>The Pilot House</street1>
                <street2>2 Atlantic Avenue, Lewis Wharf</street2>
                <city>Boston</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02110</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-05-050278</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-09-21</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Saturn Capital, Inc.</recipientName>
                <recipientCRDNumber>15412</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Saturn Capital, Inc.</street1>
                    <street2>75 Federal Street</street2>
                    <city>Boston</city>
                    <stateOrCountry>MA</stateOrCountry>
                    <zipCode>02110</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CO</state>
                    <state>CT</state>
                    <state>DE</state>
                    <state>KY</state>
                    <state>MA</state>
                    <state>NE</state>
                    <state>NH</state>
                    <state>NJ</state>
                    <state>NY</state>
                    <state>NC</state>
                    <state>OH</state>
                    <state>PA</state>
                    <state>RI</state>
                    <state>TN</state>
                    <state>VA</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>12500001</totalOfferingAmount>
            <totalAmountSold>8500001</totalAmountSold>
            <totalRemaining>4000000</totalRemaining>
            <clarificationOfResponse>Offering amount includes exercise of warrant to purchase stock. Such warrant will be issued only to placement agent.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>26</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>800000</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse>Estimated amount assumes successful sale of whole offering amount; placement agent may also be issued warrant to purchase up to 1,315,790 Series B Preferred Stock at a price of $1.90 per share.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Knopp Neurosciences Inc.</issuerName>
                <signatureName>/s/ Gregory T. Hebrank</signatureName>
                <nameOfSigner>Gregory T. Hebrank</nameOfSigner>
                <signatureTitle>Executive Vice President, Corporate Operations and Finance</signatureTitle>
                <signatureDate>2010-01-13</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----