-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 Sy3ws+8Fss3dgzYqJmQcgg==

<SEC-DOCUMENT>0001347065-10-000003.txt : 20100625
<SEC-HEADER>0001347065-10-000003.hdr.sgml : 20100625
<ACCEPTANCE-DATETIME>20100625144354
ACCESSION NUMBER:		0001347065-10-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100625
DATE AS OF CHANGE:		20100625
EFFECTIVENESS DATE:		20100625

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Decision Sciences International Corp
		CENTRAL INDEX KEY:			0001347065
		IRS NUMBER:				651261796
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-144066
		FILM NUMBER:		10917256

	BUSINESS ADDRESS:	
		STREET 1:		12345 FIRST AMERICAN WAY
		STREET 2:		SUITE 130
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92064
		BUSINESS PHONE:		8585711900

	MAIL ADDRESS:	
		STREET 1:		12345 FIRST AMERICAN WAY
		STREET 2:		SUITE 130
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92064

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Decision Sciences Corp
		DATE OF NAME CHANGE:	20051215
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001347065</cik>
        <entityName>Decision Sciences International Corp</entityName>
        <issuerAddress>
            <street1>12345 First American Way, Suite 130</street1>
            <city>Poway</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>92064</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>858-571-1900</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>DSC Reincorporation Corporation</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Decision Sciences Corp</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2009</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>J</middleName>
                <lastName>Whalen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>President and CEO</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Allan</firstName>
                <middleName>H</middleName>
                <lastName>Wegner</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Technical Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gene</firstName>
                <middleName>W</middleName>
                <lastName>Ray</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chairman of the Board</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thurston</firstName>
                <middleName>Eric</middleName>
                <lastName>Womble</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Board Member</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jay</firstName>
                <middleName>M</middleName>
                <lastName>Cohen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Board Member</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Lawrence</firstName>
                <middleName>J</middleName>
                <lastName>Delaney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Board Member</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <lastName>Lehman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>12345 First American Way, Suite 130</street1>
                <city>Poway</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>92064</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Board Member</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-06-11</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>The offer included the Company's Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock, a warrant to purchase common stock and options for the purchase of common stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>20644806</totalOfferingAmount>
            <totalAmountSold>20644806</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>$14.9M (over time) for 512,927 Series B Pref; $100k for 3,405 Series B Pref + 37,007,742 Common warrant;  189,339 Series C Pref + 57,452,124 Common options for services;  194,329 Series D Pref issued to convert $5,644,806.55(P&amp;I)debt securities.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>69</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Decision Sciences International Corp</issuerName>
                <signatureName>/Robert J Whalen/</signatureName>
                <nameOfSigner>Robert J Whalen</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2010-06-25</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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