-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001344213-10-000005.txt : 20100402
<SEC-HEADER>0001344213-10-000005.hdr.sgml : 20100402
<ACCEPTANCE-DATETIME>20100401174803
ACCESSION NUMBER:		0001344213-10-000005
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100402
DATE AS OF CHANGE:		20100401
EFFECTIVENESS DATE:		20100402

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Natrogen Therapeutics International, Inc.
		CENTRAL INDEX KEY:			0001344213
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-83126
		FILM NUMBER:		10725919

	BUSINESS ADDRESS:	
		STREET 1:		315 EAST 68TH ST.
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10065
		BUSINESS PHONE:		212-988-7490

	MAIL ADDRESS:	
		STREET 1:		315 EAST 68TH ST.
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10065

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NATROGEN THERAPEUTICS INTERNATIONAL, INC
		DATE OF NAME CHANGE:	20100325

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NATROGEN THERAPEUTICS INTERNATIONAL INC
		DATE OF NAME CHANGE:	20051114
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001344213</cik>
        <entityName>Natrogen Therapeutics International, Inc.</entityName>
        <issuerAddress>
            <street1>315 East 68th St.</street1>
            <city>New York</city>
            <stateOrCountry>NY</stateOrCountry>
            <zipCode>10065</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>212-988-7490</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>NATROGEN THERAPEUTICS INTERNATIONAL, INC</previousName>
            <previousName>NATROGEN THERAPEUTICS INTERNATIONAL INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Longgui</firstName>
                <lastName>Wang</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>45-35 166th St.</street1>
                <city>Flushing</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>11358</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Allen</firstName>
                <lastName>Tsao</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>24401 N. Windlake Road</street1>
                <city>Windlake</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53185</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Simon</firstName>
                <lastName>Mencher</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>315 East 68th St.</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10065</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>P.</middleName>
                <lastName>McCarron Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>315 East 68th St.</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10065</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Basil</firstName>
                <lastName>Hanss</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1725 York Avenue, Apt. 20B</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10128</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <lastName>Bartlett</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>315 East 68th St.</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10065</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Xiaomei</firstName>
                <lastName>Liu</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>315 East 68th St.</street1>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10065</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2007-08-27</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1867041</totalOfferingAmount>
            <totalAmountSold>1400000</totalAmountSold>
            <totalRemaining>467041</totalRemaining>
            <clarificationOfResponse>Includes the sale and issuance of 4,971 shares of Common Stock and Warrants to purchase 1,657 shares of Common Stock, both at $281.69 per share.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>6</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Natrogen Therapeutics International, Inc.</issuerName>
                <signatureName>/s/ Longgui Wang</signatureName>
                <nameOfSigner>Longgui Wang</nameOfSigner>
                <signatureTitle>President</signatureTitle>
                <signatureDate>2010-04-01</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----