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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001335480-09-000004.txt : 20091030
<SEC-HEADER>0001335480-09-000004.hdr.sgml : 20091030
<ACCEPTANCE-DATETIME>20091030152318
ACCESSION NUMBER:		0001335480-09-000004
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091030
DATE AS OF CHANGE:		20091030
EFFECTIVENESS DATE:		20091030

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			XANODYNE PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001335480
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-79890
		FILM NUMBER:		091147936

	BUSINESS ADDRESS:	
		STREET 1:		ONE RIVERFRONT PLACE
		CITY:			NEWPORT
		STATE:			KY
		ZIP:			41071
		BUSINESS PHONE:		8593717581

	MAIL ADDRESS:	
		STREET 1:		ONE RIVERFRONT PLACE
		CITY:			NEWPORT
		STATE:			KY
		ZIP:			41071
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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        <entityName>XANODYNE PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>ONE RIVERFRONT PLACE</street1>
            <city>NEWPORT</city>
            <stateOrCountry>KY</stateOrCountry>
            <zipCode>41071</zipCode>
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        <issuerPhoneNumber>8593717581</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dennis</firstName>
                <lastName>Purcell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Steven</firstName>
                <lastName>St. Peter</lastName>
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            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Vaughn</firstName>
                <middleName>M.</middleName>
                <lastName>Kailian</lastName>
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                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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                <firstName>Michael</firstName>
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                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
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                <relationship>Director</relationship>
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            <relatedPersonName>
                <firstName>Rolf</firstName>
                <middleName>A.</middleName>
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                <city>Newport</city>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Shannon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
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                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>P.</middleName>
                <lastName>Jennings</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
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                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kevin</firstName>
                <middleName>T.</middleName>
                <lastName>Anderson</lastName>
            </relatedPersonName>
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                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gary</firstName>
                <middleName>A.</middleName>
                <lastName>Shangold</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Daniel</firstName>
                <middleName>W.</middleName>
                <lastName>Docherty</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <lastName>Wentworth</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Natasha</firstName>
                <lastName>Giordano</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Rita</firstName>
                <middleName>M.</middleName>
                <lastName>O'Connor</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patrick</firstName>
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            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
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                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001335480-09-000002</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Aquilo Partners, L.P.</recipientName>
                <recipientCRDNumber>114909</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>One Maritime Plaza</street1>
                    <street2>14th Floor</street2>
                    <city>San Francisco</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>94111</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>87783861</totalOfferingAmount>
            <totalAmountSold>87783861</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>35</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>1108768</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>XANODYNE PHARMACEUTICALS INC</issuerName>
                <signatureName>/s/ Thomas P. Jennings</signatureName>
                <nameOfSigner>Thomas P. Jennings</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2009-10-30</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----