-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Jb22S+LYhixwVTdzfy9JZb24dZyT4AZdyr7V7hdxuRUmQx/bn1xm0ooU2CYWJkb3
 i0Q3VecvlHx7mLMSJb3cQw==

<SEC-DOCUMENT>0001335480-09-000002.txt : 20090521
<SEC-HEADER>0001335480-09-000002.hdr.sgml : 20090521
<ACCEPTANCE-DATETIME>20090521092128
ACCESSION NUMBER:		0001335480-09-000002
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090521
DATE AS OF CHANGE:		20090521
EFFECTIVENESS DATE:		20090521

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			XANODYNE PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001335480
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-79890
		FILM NUMBER:		09844138

	BUSINESS ADDRESS:	
		STREET 1:		ONE RIVERFRONT PLACE
		CITY:			NEWPORT
		STATE:			KY
		ZIP:			41071
		BUSINESS PHONE:		8593717581

	MAIL ADDRESS:	
		STREET 1:		ONE RIVERFRONT PLACE
		CITY:			NEWPORT
		STATE:			KY
		ZIP:			41071
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001335480</cik>
        <entityName>XANODYNE PHARMACEUTICALS INC</entityName>
        <issuerAddress>
            <street1>ONE RIVERFRONT PLACE</street1>
            <street2></street2>
            <city>NEWPORT</city>
            <stateOrCountry>KY</stateOrCountry>
            <zipCode>41071</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>8593716383</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dennis</firstName>
                <middleName></middleName>
                <lastName>Purcell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <middleName></middleName>
                <lastName>St. Peter</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Vaughan</firstName>
                <middleName>M.</middleName>
                <lastName>Kailian</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName></middleName>
                <lastName>Valentino</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Rolf</firstName>
                <middleName>A.</middleName>
                <lastName>Classon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Craig</firstName>
                <middleName></middleName>
                <lastName>Tooman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName></middleName>
                <lastName>Shannon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <middleName>A.</middleName>
                <lastName>Stamp</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>P.</middleName>
                <lastName>Jennings</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kevin</firstName>
                <middleName>T.</middleName>
                <lastName>Anderson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gary</firstName>
                <middleName>A.</middleName>
                <lastName>Shangold</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Timothy</firstName>
                <middleName></middleName>
                <lastName>Arendt</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Daniel</firstName>
                <middleName>W.</middleName>
                <lastName>Docherty</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Riverfront Place</street1>
                <street2></street2>
                <city>Newport</city>
                <stateOrCountry>KY</stateOrCountry>
                <zipCode>41071</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>75000000</totalOfferingAmount>
            <totalAmountSold>37783864</totalAmountSold>
            <totalRemaining>37216136</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>25</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>XANODYNE PHARMACEUTICALS INC</issuerName>
                <signatureName>/S/ Thomas P. Jennings</signatureName>
                <nameOfSigner>Thomas P. Jennings</nameOfSigner>
                <signatureTitle>Secretary</signatureTitle>
                <signatureDate>2009-05-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----