-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001327783-10-000006.txt : 20100317
<SEC-HEADER>0001327783-10-000006.hdr.sgml : 20100317
<ACCEPTANCE-DATETIME>20100317115333
ACCESSION NUMBER:		0001327783-10-000006
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100317
DATE AS OF CHANGE:		20100317
EFFECTIVENESS DATE:		20100317

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ODYSSEY THERA INC.
		CENTRAL INDEX KEY:			0001327783
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-77176
		FILM NUMBER:		10688006

	BUSINESS ADDRESS:	
		STREET 1:		4550 NORRIS CANYON ROAD
		STREET 2:		SUITE 140
		CITY:			SAN RAMON
		STATE:			CA
		ZIP:			94583
		BUSINESS PHONE:		925-242-5000

	MAIL ADDRESS:	
		STREET 1:		4550 NORRIS CANYON ROAD
		STREET 2:		SUITE 140
		CITY:			SAN RAMON
		STATE:			CA
		ZIP:			94583

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Odyssey Thera Inc
		DATE OF NAME CHANGE:	20050519
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001327783</cik>
        <entityName>ODYSSEY THERA INC.</entityName>
        <issuerAddress>
            <street1>4550 NORRIS CANYON ROAD</street1>
            <street2>SUITE 140</street2>
            <city>SAN RAMON</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94583</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>925-242-5000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Odyssey Thera Inc</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Westwick</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Odyssey Thera, Inc.</street1>
                <street2>4550 Norris Canyon Road, Suite 140</street2>
                <city>San Ramon</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94583</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hugh</firstName>
                <lastName>Reinhoff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2729 Debbie Court</street1>
                <city>San Carlos</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94070</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Caskey</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Univ. of Texas, Health Sci. Center</street1>
                <street2>2121 W. Holcombe Blvd., Suite 900</street2>
                <city>Houston</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77030</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bryant</firstName>
                <lastName>Fong</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Burrill &amp; Company</street1>
                <street2>One Embarcadero Center, Suite 2700</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94111</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alan</firstName>
                <lastName>Sachs</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Merck / Sirna Therapeutics</street1>
                <street2>1700 Owens Street, 4th Floor</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94158</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-02-17</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3499999</totalOfferingAmount>
            <totalAmountSold>3499999</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ODYSSEY THERA INC.</issuerName>
                <signatureName>/s/Diane L. Rose</signatureName>
                <nameOfSigner>Diane L. Rose</nameOfSigner>
                <signatureTitle>Under Power of Attorney dated 03/10/2010</signatureTitle>
                <signatureDate>2010-03-17</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----