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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 acqssG+r6ai84fQ61YhZhw==

<SEC-DOCUMENT>0000950103-10-003187.txt : 20101101
<SEC-HEADER>0000950103-10-003187.hdr.sgml : 20101101
<ACCEPTANCE-DATETIME>20101101111710
ACCESSION NUMBER:		0000950103-10-003187
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Investment Company Act Section 3(c)
ITEM INFORMATION:		Section 3(c)(7)
FILED AS OF DATE:		20101101
DATE AS OF CHANGE:		20101101
EFFECTIVENESS DATE:		20101101

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FrontPoint Offshore Healthcare Flagship Fund, L.P.
		CENTRAL INDEX KEY:			0001299058
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			E9

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-67878
		FILM NUMBER:		101153816

	BUSINESS ADDRESS:	
		STREET 1:		TWO GREENWICH PLAZA
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		(203) 622-5200

	MAIL ADDRESS:	
		STREET 1:		TWO GREENWICH PLAZA
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FRONTPOINT OFFSHORE HEALTHCARE FUND LP
		DATE OF NAME CHANGE:	20040729
</SEC-HEADER>
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<TYPE>D/A
<SEQUENCE>1
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        <entityName>FrontPoint Offshore Healthcare Flagship Fund, L.P.</entityName>
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            <street1>TWO GREENWICH PLAZA</street1>
            <city>GREENWICH</city>
            <stateOrCountry>CT</stateOrCountry>
            <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
            <zipCode>06830</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(203) 622-5200</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>FrontPoint Offshore Healthcare Fund, L.P.</previousName>
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                <lastName>FrontPoint Healthcare Flagship Fund GP, LLC</lastName>
            </relatedPersonName>
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                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
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                <firstName>-</firstName>
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        <relatedPersonInfo>
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                <firstName>Eric</firstName>
                <lastName>Mendelsohn</lastName>
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                <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
                <zipCode>06830</zipCode>
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                <firstName>Taki</firstName>
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                <firstName>Joseph</firstName>
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                <lastName>Skowron III</lastName>
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                <stateOrCountry>CT</stateOrCountry>
                <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
                <zipCode>06830</zipCode>
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                <firstName>Jason</firstName>
                <lastName>Bonadio</lastName>
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                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ajay</firstName>
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            </relatedPersonName>
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                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
                <zipCode>06830</zipCode>
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            <relatedPersonRelationshipList>
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            <relationshipClarification></relationshipClarification>
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    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0000950103-10-000732</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2003-05-07</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>100000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>1018096771</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>34</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
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            <clarificationOfResponse></clarificationOfResponse>
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        <useOfProceeds>
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                <dollarAmount>0</dollarAmount>
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        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>FrontPoint Offshore Healthcare Flagship Fund, L.P.</issuerName>
                <signatureName>/s/ T.A. McKinney</signatureName>
                <nameOfSigner>T.A. McKinney</nameOfSigner>
                <signatureTitle>Authorized Signatory</signatureTitle>
                <signatureDate>2010-11-01</signatureDate>
            </signature>
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