-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 jIA3M9NWP/gVFS0qdui9ew==

<SEC-DOCUMENT>0001274375-10-000001.txt : 20100224
<SEC-HEADER>0001274375-10-000001.hdr.sgml : 20100224
<ACCEPTANCE-DATETIME>20100224145434
ACCESSION NUMBER:		0001274375-10-000001
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Securities Act Section 4(6)
FILED AS OF DATE:		20100224
DATE AS OF CHANGE:		20100224
EFFECTIVENESS DATE:		20100224

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PATIENTSAFE SOLUTIONS, INC.
		CENTRAL INDEX KEY:			0001274375
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-61449
		FILM NUMBER:		10629495

	BUSINESS ADDRESS:	
		STREET 1:		5375 MIRA SORRENTO PLACE
		STREET 2:		SUITE 500
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		(858) 746-3100

	MAIL ADDRESS:	
		STREET 1:		5375 MIRA SORRENTO PLACE
		STREET 2:		SUITE 500
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INTELLIDOT CORP
		DATE OF NAME CHANGE:	20031224
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001274375</cik>
        <entityName>PATIENTSAFE SOLUTIONS, INC.</entityName>
        <issuerAddress>
            <street1>5375 MIRA SORRENTO PLACE</street1>
            <street2>SUITE 500</street2>
            <city>SAN DIEGO</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>92121</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(858) 746-3100</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>INTELLIDOT CORP</previousName>
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            <overFiveYears>true</overFiveYears>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JAMES</firstName>
                <lastName>SWEENEY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DOUG</firstName>
                <lastName>CARLISLE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 SAND HILL ROAD, BLDG 4</street1>
                <street2>SUITE 100</street2>
                <city>MENLO PARK</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94025</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>LISA</firstName>
                <lastName>SUENNEN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>21 TAMAL VISTA BOULEVARD</street1>
                <street2>SUITE 194</street2>
                <city>CORTE MADERA</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94925</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SHAWN</firstName>
                <middleName>M.</middleName>
                <lastName>ORR</lastName>
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            <relatedPersonAddress>
                <street1>5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RICK</firstName>
                <lastName>NORLING</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O 5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>KEITH</firstName>
                <lastName>GROSSMAN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O 5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>CHRISTOPHER</firstName>
                <lastName>KERSEY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O 5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>LARRY</firstName>
                <lastName>GRANDIA</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O 5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>GREGG</firstName>
                <lastName>IMAMOTO</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RAY</firstName>
                <middleName>A.</middleName>
                <lastName>GHANBARI</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>TIM</firstName>
                <lastName>RICH</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SI</firstName>
                <lastName>LUO</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>5375 MIRA SORRENTO PLACE</street1>
                <street2>SUITE 500</street2>
                <city>SAN DIEGO</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>46</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001274375-09-000007</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-04-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>30683180</totalOfferingAmount>
            <totalAmountSold>23824422</totalAmountSold>
            <totalRemaining>6858758</totalRemaining>
            <clarificationOfResponse>INCLUDES AMOUNTS RECEIVABLE BY THE COMPANY UPON THE EXERCISE OF A WARRANT TO PURCHASE SHARES OF THE COMPANY'S PREFERRED STOCK (ASSUMING NO NET EXERCISE).  THE WARRANT HAS NOT YET BEEN EXERCISED.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>34</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>PATIENTSAFE SOLUTIONS, INC.</issuerName>
                <signatureName>/S/ JAMES M. SWEENEY</signatureName>
                <nameOfSigner>JAMES M. SWEENEY</nameOfSigner>
                <signatureTitle>PRESIDENT AND CEO</signatureTitle>
                <signatureDate>2010-02-23</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
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</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----