-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 w6EMVmoh0cWxHcoOzLcwMw==

<SEC-DOCUMENT>0001266146-09-000007.txt : 20090908
<SEC-HEADER>0001266146-09-000007.hdr.sgml : 20090907
<ACCEPTANCE-DATETIME>20090908105515
ACCESSION NUMBER:		0001266146-09-000007
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090908
DATE AS OF CHANGE:		20090908
EFFECTIVENESS DATE:		20090908

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDSPHERE SYSTEMS CORP
		CENTRAL INDEX KEY:			0001266146
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-59110
		FILM NUMBER:		091057355

	BUSINESS ADDRESS:	
		STREET 1:		1917 PALOMAR OAKS WAY, SUITE 200
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008
		BUSINESS PHONE:		7606923705

	MAIL ADDRESS:	
		STREET 1:		1917 PALOMAR OAKS WAY, SUITE 200
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92008
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001266146</cik>
        <entityName>MEDSPHERE SYSTEMS CORP</entityName>
        <issuerAddress>
            <street1>1917 PALOMAR OAKS WAY, SUITE 200</street1>
            <street2></street2>
            <city>CARLSBAD</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>92008</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>7606923705</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kenneth</firstName>
                <middleName></middleName>
                <lastName>Kizer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Larry</firstName>
                <middleName></middleName>
                <lastName>Augustin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Nicholaus</firstName>
                <middleName></middleName>
                <lastName>Efstratis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One South Main Street, 8th Floor</street1>
                <street2></street2>
                <city>Salt Lake City</city>
                <stateOrCountry>UT</stateOrCountry>
                <zipCode>84111</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Randall</firstName>
                <middleName></middleName>
                <lastName>Prust</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mike</firstName>
                <middleName></middleName>
                <lastName>Kwatinez</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName></middleName>
                <lastName>Doyle</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Rick</firstName>
                <middleName></middleName>
                <lastName>Jung</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Edmund</firstName>
                <middleName></middleName>
                <lastName>Billings</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Irv</firstName>
                <middleName></middleName>
                <lastName>Lichtenwald</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1917 Palomar Oaks Way, Suite 200</street1>
                <street2></street2>
                <city>Carlsbad</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92008-5512</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Technology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001266146-09-000006</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-05</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Series 1 Preferred Stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>15000000</totalOfferingAmount>
            <totalAmountSold>8676152</totalAmountSold>
            <totalRemaining>6323848</totalRemaining>
            <clarificationOfResponse>The actual Total Amount Sold is $8,676,151.47</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>32</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>MEDSPHERE SYSTEMS CORP</issuerName>
                <signatureName>Irv Lichtenwald</signatureName>
                <nameOfSigner>Irv Lichtenwald</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-09-08</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----