-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 tM8eUAsMxUcgyVXpiai7CQ==

<SEC-DOCUMENT>0001209191-10-055526.txt : 20101117
<SEC-HEADER>0001209191-10-055526.hdr.sgml : 20101117
<ACCEPTANCE-DATETIME>20101117163357
ACCESSION NUMBER:		0001209191-10-055526
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20101117
DATE AS OF CHANGE:		20101117
EFFECTIVENESS DATE:		20101117

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ZONARE MEDICAL SYSTEMS INC
		CENTRAL INDEX KEY:			0001259208
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-150660
		FILM NUMBER:		101200146

	BUSINESS ADDRESS:	
		STREET 1:		420 NORTH BERNARDO AVENUE
		CITY:			MOUNTAIN VIEW
		STATE:			CA
		ZIP:			94043
		BUSINESS PHONE:		6502302800

	MAIL ADDRESS:	
		STREET 1:		420 NORTH BERNARDO AVENUE
		CITY:			MOUNTAIN VIEW
		STATE:			CA
		ZIP:			94043
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <cik>0001259208</cik>
        <entityName>ZONARE MEDICAL SYSTEMS INC</entityName>
        <issuerAddress>
            <street1>420 North Bernardo Avenue</street1>
            <city>Mountain View</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>94043-1839</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(650) 230-2800</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>NovaSonics, Inc.</previousName>
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            <value>None</value>
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        <entityType>Corporation</entityType>
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            <overFiveYears>true</overFiveYears>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jay</firstName>
                <middleName>D.</middleName>
                <lastName>Miller</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94043-1839</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Timothy</firstName>
                <middleName>A.</middleName>
                <lastName>Marcotte</lastName>
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            <relatedPersonAddress>
                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
                <city>Mountain View</city>
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                <zipCode>94043-1839</zipCode>
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                <firstName>Joseph</firstName>
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                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
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                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94043-1839</zipCode>
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            <relatedPersonName>
                <firstName>Glen</firstName>
                <middleName>W.</middleName>
                <lastName>McLaughlin</lastName>
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            <relatedPersonAddress>
                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
                <city>Mountain View</city>
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                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94043-1839</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Nader</firstName>
                <lastName>Naini</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Frazier Healthcare Ventures</street1>
                <street2>601 Union Street, Suite 3200</street2>
                <city>Seattle</city>
                <stateOrCountry>WA</stateOrCountry>
                <stateOrCountryDescription>WASHINGTON</stateOrCountryDescription>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thom</firstName>
                <middleName>E.</middleName>
                <lastName>Rasche</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Earlybird Verwaltungs GmbH</street1>
                <street2>Van-der-smissen Strasse 3</street2>
                <city>Hamburg</city>
                <stateOrCountry>2M</stateOrCountry>
                <stateOrCountryDescription>GERMANY</stateOrCountryDescription>
                <zipCode>22767</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Douglas</firstName>
                <middleName>W.</middleName>
                <lastName>Tefft</lastName>
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            <relatedPersonAddress>
                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94043-1839</zipCode>
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            <relatedPersonName>
                <firstName>Mark</firstName>
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                <lastName>Miller</lastName>
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            <relatedPersonAddress>
                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
                <city>Mountain View</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94043-1839</zipCode>
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            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>J.</middleName>
                <lastName>Gallagher</lastName>
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            <relatedPersonAddress>
                <street1>c/o ZONARE Medical Systems, Inc.</street1>
                <street2>420 North Bernardo Avenue</street2>
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                <stateOrCountry>CA</stateOrCountry>
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                <zipCode>94043-1839</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <lastName>Hollywood</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Apposite Capital LLP</street1>
                <street2>Bracken House, One Friday Street</street2>
                <city>London</city>
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                <stateOrCountryDescription>UNITED KINGDOM</stateOrCountryDescription>
                <zipCode>EC4M9JA</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-11-12</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3000000</totalOfferingAmount>
            <totalAmountSold>1171540</totalAmountSold>
            <totalRemaining>1828460</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>8</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ZONARE MEDICAL SYSTEMS INC</issuerName>
                <signatureName>/s/ Timothy A. Marcotte</signatureName>
                <nameOfSigner>Timothy A. Marcotte</nameOfSigner>
                <signatureTitle>Vice President and Chief Financial Officer</signatureTitle>
                <signatureDate>2010-11-17</signatureDate>
            </signature>
        </signatureBlock>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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