-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 BsMmtOm4hhQApBuS+a8+a2T8WeJ3SFRBWDKHt4CiRa6gzuTyoZ+AliWs1T62KiJj
 LljygcCkYiQvScM12C01dQ==

<SEC-DOCUMENT>0001254728-09-000003.txt : 20090504
<SEC-HEADER>0001254728-09-000003.hdr.sgml : 20090504
<ACCEPTANCE-DATETIME>20090504114218
ACCESSION NUMBER:		0001254728-09-000003
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090504
DATE AS OF CHANGE:		20090504
EFFECTIVENESS DATE:		20090504

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CRYSTALPLEX CORP
		CENTRAL INDEX KEY:			0001254728
		IRS NUMBER:				260040719
		STATE OF INCORPORATION:			PA

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-56966
		FILM NUMBER:		09792186

	BUSINESS ADDRESS:	
		STREET 1:		2403 SIDNEY ST
		STREET 2:		STE 280
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203
		BUSINESS PHONE:		412-246-2044

	MAIL ADDRESS:	
		STREET 1:		2403 SIDNEY ST
		STREET 2:		STE 280
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15203
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001254728</cik>
        <entityName>CRYSTALPLEX CORP</entityName>
        <issuerAddress>
            <street1>2403 SIDNEY ST</street1>
            <street2>STE 280</street2>
            <city>PITTSBURGH</city>
            <stateOrCountry>PA</stateOrCountry>
            <zipCode>15203</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>412-246-2044</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>PA</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Matthew</firstName>
                <middleName></middleName>
                <lastName>Bootman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2403 Sidney Street</street1>
                <street2>Ste. 280</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName></middleName>
                <lastName>Petzinger</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>LaunchCyte LLC</street1>
                <street2>2403 Sidney St.., Ste. 271</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Matthew</firstName>
                <middleName></middleName>
                <lastName>Oristano</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Alda L.P.</street1>
                <street2>1764 Litchfield Turnpike, #203</street2>
                <city>Woodbridge</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06525</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Charles</firstName>
                <middleName></middleName>
                <lastName>Wozniak</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Creekside Springs</street1>
                <street2>667 Merchant St.</street2>
                <city>Ambridge</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15003</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>J.</middleName>
                <lastName>Sieper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>475 Crestmont Drive</street1>
                <street2></street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94131</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Lianhua</firstName>
                <middleName></middleName>
                <lastName>Qu</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2403 Sidney Street</street1>
                <street2>Ste. 280</street2>
                <city>Pittsburgh</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>15203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-09-011460</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-01-14</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>5000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1500000</totalOfferingAmount>
            <totalAmountSold>225000</totalAmountSold>
            <totalRemaining>1275000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>150000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CRYSTALPLEX CORP</issuerName>
                <signatureName>MATTHEW BOOTMAN</signatureName>
                <nameOfSigner>Matthew Bootman</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2009-05-04</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----