-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
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 Qxqv5tuBZ/LGIwRcAiFUOA==

<SEC-DOCUMENT>0001203928-09-000005.txt : 20090804
<SEC-HEADER>0001203928-09-000005.hdr.sgml : 20090804
<ACCEPTANCE-DATETIME>20090804103556
ACCESSION NUMBER:		0001203928-09-000005
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090804
DATE AS OF CHANGE:		20090804
EFFECTIVENESS DATE:		20090804

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OTHERA PHARMACEUTICALS, INC
		CENTRAL INDEX KEY:			0001203928
		IRS NUMBER:				752983920
		STATE OF INCORPORATION:			PA
		FISCAL YEAR END:			1209

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-49840
		FILM NUMBER:		09982081

	BUSINESS ADDRESS:	
		STREET 1:		730 SPRINGDALE DRIVE
		CITY:			EXTON
		STATE:			PA
		ZIP:			19341
		BUSINESS PHONE:		484-879-2800

	MAIL ADDRESS:	
		STREET 1:		730 SPRINGDALE DRIVE
		CITY:			EXTON
		STATE:			PA
		ZIP:			19341

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OTHERA PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20021106
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001203928</cik>
        <entityName>OTHERA PHARMACEUTICALS, INC</entityName>
        <issuerAddress>
            <street1>730 SPRINGDALE DRIVE</street1>
            <street2></street2>
            <city>EXTON</city>
            <stateOrCountry>PA</stateOrCountry>
            <zipCode>19341</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>484-879-2800</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>OTHERA PHARMACEUTICALS INC</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>PENNSYLVANIA</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>S.</middleName>
                <lastName>Joseph</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Othera Pharmaceuticals, Inc.</street1>
                <street2>730 Springdale Drive</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>R.</middleName>
                <lastName>Morse</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Liberty Venture Partners</street1>
                <street2>2005 Market Street, Suite 2040</street2>
                <city>Philadelphia</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19103</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hans</firstName>
                <middleName></middleName>
                <lastName>Mueller</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o hmConsulting</street1>
                <street2>1802 Chestnut Hollow Lane</street2>
                <city>West Chester</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19382</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <middleName>G.</middleName>
                <lastName>Murphy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o New Spring Ventures, L.P.</street1>
                <street2>500 North Gulph Road, Suite 500</street2>
                <city>King of Prussia</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19406</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Katherine</firstName>
                <middleName></middleName>
                <lastName>Crothall</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Othera Pharmaceuticals, Inc.</street1>
                <street2>730 Springdale Drive</street2>
                <city>Exton</city>
                <stateOrCountry>PA</stateOrCountry>
                <zipCode>19341</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Rami</firstName>
                <middleName></middleName>
                <lastName>Elghandour</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Johnson and Johnson Dev. Corp.</street1>
                <street2>410 George Street</street2>
                <city>New Brunswick</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08901</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001203928-09-000004</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-10-10</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>10769994</totalOfferingAmount>
            <totalAmountSold>10619994</totalAmountSold>
            <totalRemaining>150000</totalRemaining>
            <clarificationOfResponse>Further proceeds include exercise price of Warrants to be issued at a later date, which exercise price is not yet determinable, and Warrants to purchase shares of Series C Convertible Preferred Stock at an aggregate exercise price of $1,769,994.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>26</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>350000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>OTHERA PHARMACEUTICALS, INC</issuerName>
                <signatureName>Philip Heifetz</signatureName>
                <nameOfSigner>Philip Heifetz</nameOfSigner>
                <signatureTitle>Vice President</signatureTitle>
                <signatureDate>2009-08-04</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----