-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 EViLOPi5k8XK9SvKjVh6SBQi8d/VVb78EInr3vYi75z5Z7FhBpZ4vH3v1Txe11cR
 27GN7xM8bj2PXbfjrd46cQ==

<SEC-DOCUMENT>0001181431-10-002975.txt : 20100113
<SEC-HEADER>0001181431-10-002975.hdr.sgml : 20100113
<ACCEPTANCE-DATETIME>20100113171408
ACCESSION NUMBER:		0001181431-10-002975
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100113
DATE AS OF CHANGE:		20100113
EFFECTIVENESS DATE:		20100113

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORAGENICS INC
		CENTRAL INDEX KEY:			0001174940
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				593410522
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-137786
		FILM NUMBER:		10525790

	BUSINESS ADDRESS:	
		STREET 1:		12085 RESEARCH DRIVE
		CITY:			ALACHUA
		STATE:			FL
		ZIP:			32615
		BUSINESS PHONE:		3864184018

	MAIL ADDRESS:	
		STREET 1:		12085 RESEARCH DRIVE
		CITY:			ALACHUA
		STATE:			FL
		ZIP:			32615
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001174940</cik>
        <entityName>ORAGENICS INC</entityName>
        <issuerAddress>
            <street1>13700 Progress Blvd.</street1>
            <city>Alachua</city>
            <stateOrCountry>FL</stateOrCountry>
            <zipCode>32615</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>386-418-4018</issuerPhoneNumber>
        <jurisdictionOfInc>FLORIDA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Oragen, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>Brian</middleName>
                <lastName>Hirsch</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Bayport Drive</street1>
                <street2>Suite 685</street2>
                <city>Tampa</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>33607</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <lastName>Bohunicky</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>13700 Progress Blvd.</street1>
                <city>Alachua</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>32615</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeffrey</firstName>
                <lastName>Hillman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>13700 Progress Blvd.</street1>
                <city>Alachua</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>32615</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christine</firstName>
                <lastName>Koski</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1500 West University Parkway</street1>
                <city>Sarasota</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>34243</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Koski</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1500 West University Parkway</street1>
                <city>Sarasota</city>
                <stateOrCountry>FL</stateOrCountry>
                <zipCode>34243</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-12-30</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3000000</totalOfferingAmount>
            <totalAmountSold>3000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Excludes $1,000,000 in offering of common stock in exchange for $1,000,000 outstanding secured debt which was condition of transaction.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>9</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>While no proceeds were paid, we did issue shares to satisfy $54,062.50 owed to Chief Scientific Officer Jeff Hillman and $1.0M secured debt owed to the Koski FLP.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ORAGENICS INC</issuerName>
                <signatureName>/s/ David Hirsch</signatureName>
                <nameOfSigner>David Hirsch</nameOfSigner>
                <signatureTitle>President and Chief Executive Officer</signatureTitle>
                <signatureDate>2010-01-13</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----