-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 SRwRhhqyeVfmnUyeEnXYhGHhBXjPY9eRfJeypZT1Y/DA3Fewvk67uJD2r+jjKepi
 CYHhmlOWfPvoW7CrHTCEDQ==

<SEC-DOCUMENT>0001171623-09-000004.txt : 20090826
<SEC-HEADER>0001171623-09-000004.hdr.sgml : 20090826
<ACCEPTANCE-DATETIME>20090826095708
ACCESSION NUMBER:		0001171623-09-000004
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090826
DATE AS OF CHANGE:		20090826
EFFECTIVENESS DATE:		20090826

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DIFFUSION PHARMACEUTICALS LLC
		CENTRAL INDEX KEY:			0001171623
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			VA

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-43456
		FILM NUMBER:		091035308

	BUSINESS ADDRESS:	
		STREET 1:		2020 AVON COURT, #4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
		BUSINESS PHONE:		434-220-0718

	MAIL ADDRESS:	
		STREET 1:		2020 AVON COURT, #4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001171623</cik>
        <entityName>DIFFUSION PHARMACEUTICALS LLC</entityName>
        <issuerAddress>
            <street1>2020 AVON COURT, #4</street1>
            <street2></street2>
            <city>CHARLOTTESVILLE</city>
            <stateOrCountry>VA</stateOrCountry>
            <zipCode>22902</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>434-220-0718</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>VIRGINIA</jurisdictionOfInc>
        <entityType>Limited Liability Company</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Kalergis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court, #4</street1>
                <street2></street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>L.</middleName>
                <lastName>Gainer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court, #4</street1>
                <street2></street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>E.</middleName>
                <lastName>Byrne</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1400 North 14th Street</street1>
                <street2></street2>
                <city>Arlington</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22209</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>W.</middleName>
                <lastName>Adams</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>901 North Glebe Road</street1>
                <street2>11th Floor</street2>
                <city>Arlington</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22203</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ben</firstName>
                <middleName>L.</middleName>
                <lastName>Shealy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court, #4</street1>
                <street2></street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Matthew</firstName>
                <middleName></middleName>
                <lastName>Hantzmon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court, #4</street1>
                <street2></street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <middleName>T.</middleName>
                <lastName>Giles</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>380 Spring Lane</street1>
                <street2></street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-07-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5000001</totalOfferingAmount>
            <totalAmountSold>1803728</totalAmountSold>
            <totalRemaining>3196273</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>14</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>425000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>DIFFUSION PHARMACEUTICALS LLC</issuerName>
                <signatureName>David G. Kalergis</signatureName>
                <nameOfSigner>David G. Kalergis</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2009-08-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----