-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 HAgxsC7QhVw0S1Hm3rPjuQ==

<SEC-DOCUMENT>0001125941-09-000007.txt : 20090928
<SEC-HEADER>0001125941-09-000007.hdr.sgml : 20090928
<ACCEPTANCE-DATETIME>20090928162534
ACCESSION NUMBER:		0001125941-09-000007
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090928
DATE AS OF CHANGE:		20090928
EFFECTIVENESS DATE:		20090928

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CALYPSO MEDICAL TECHNOLOGIES INC
		CENTRAL INDEX KEY:			0001125941
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-72616
		FILM NUMBER:		091090477

	BUSINESS ADDRESS:	
		STREET 1:		4TH & BLANCHARD BUILDING
		STREET 2:		2101 FOURTH AVENUE, SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121
		BUSINESS PHONE:		206-254-0600

	MAIL ADDRESS:	
		STREET 1:		4TH & BLANCHARD BUILDING
		STREET 2:		2101 FOURTH AVENUE, SUITE 500
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98121
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001125941</cik>
        <entityName>CALYPSO MEDICAL TECHNOLOGIES INC</entityName>
        <issuerAddress>
            <street1>4TH &amp; BLANCHARD BUILDING</street1>
            <street2>2101 FOURTH AVENUE, SUITE 500</street2>
            <city>SEATTLE</city>
            <stateOrCountry>WA</stateOrCountry>
            <zipCode>98121</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>206-254-0600</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Calamari Medical, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eric</firstName>
                <lastName>Meier</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4th &amp; Blanchard Building</street1>
                <street2>2101 4th Avenue, Suite 500</street2>
                <city>Seattle</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Freund</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>525 University Avenue, Suite 520</street1>
                <city>Palo Alto</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeanne</firstName>
                <lastName>Cunicelli</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>750 Battery Street, Suite 400</street1>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94111</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alan</firstName>
                <lastName>Levy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>601 Union Street, Suite 3200</street1>
                <city>Seattle</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ross</firstName>
                <lastName>Jaffe</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>3000 Sand Hill Road, Bldg. 1, Suite 260</street1>
                <city>Menlo Park</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94025</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Trever</firstName>
                <lastName>Moody</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>601 Union Street, Suite 3200</street1>
                <city>Seattle</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Gill</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o 4th &amp; Blanchard Building</street1>
                <street2>2101 4th Avenue, Suite 500</street2>
                <city>Seattle</city>
                <stateOrCountry>WA</stateOrCountry>
                <zipCode>98121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Sweeney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2710 Sand Hill Road, Second Floor</street1>
                <city>Menlo Park</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94025</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other Health Care</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-09-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Leerink Swann LLC</recipientName>
                <recipientCRDNumber>39011</recipientCRDNumber>
                <associatedBDName>Leerink Swann LLC</associatedBDName>
                <associatedBDCRDNumber>39011</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1 Federal Street 37th Floor</street1>
                    <city>Boston</city>
                    <stateOrCountry>MA</stateOrCountry>
                    <zipCode>02110</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>IL</state>
                    <state>MD</state>
                    <state>MA</state>
                    <state>MN</state>
                    <state>NY</state>
                    <state>TX</state>
                    <state>UT</state>
                    <state>WA</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>51830895</totalOfferingAmount>
            <totalAmountSold>48363045</totalAmountSold>
            <totalRemaining>3467850</totalRemaining>
            <clarificationOfResponse>$1,690,236 of the Total Offering Amount represents the aggregate exercise price for warrants to purchase shares of Series A-1 Preferred Stock pursuant to the Convertible Note and Warrant Purchase Agreement dated 4/22/09.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>41</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>1215000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>19458</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Additional commission includes warrants to purchase up to 3,808,777 shares of Series A-1 Preferred Stock at $0.10 per share.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CALYPSO MEDICAL TECHNOLOGIES INC</issuerName>
                <signatureName>/s/Mark Querry</signatureName>
                <nameOfSigner>Mark Querry</nameOfSigner>
                <signatureTitle>Vice President, Commercial Operations</signatureTitle>
                <signatureDate>2009-09-24</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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