-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 FIy18Zeh3HiKBf+KPA79AdEzX8Z7TZ4Iq5GexZcqXbXOu8eckQ25undAsf5YEZuY
 NHQF2J0e95b+CCuxlfJLwg==

<SEC-DOCUMENT>0001288230-09-000002.txt : 20090929
<SEC-HEADER>0001288230-09-000002.hdr.sgml : 20090929
<ACCEPTANCE-DATETIME>20090929155923
ACCESSION NUMBER:		0001288230-09-000002
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090929
DATE AS OF CHANGE:		20090929
EFFECTIVENESS DATE:		20090929

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ZIOPHARM ONCOLOGY INC
		CENTRAL INDEX KEY:			0001107421
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-SPECIALTY OUTPATIENT FACILITIES, NEC [8093]
		IRS NUMBER:				841475642
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-82500
		FILM NUMBER:		091092997

	BUSINESS ADDRESS:	
		STREET 1:		1180 AVENUE OF THE AMERICA
		STREET 2:		19TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		646-214-0700

	MAIL ADDRESS:	
		STREET 1:		1180 AVENUE OF THE AMERICA
		STREET 2:		19TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EASYWEB INC
		DATE OF NAME CHANGE:	20010213
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001107421</cik>
        <entityName>ZIOPHARM ONCOLOGY INC</entityName>
        <issuerAddress>
            <street1>1180 AVENUE OF THE AMERICA</street1>
            <street2>19TH FLOOR</street2>
            <city>NEW YORK</city>
            <stateOrCountry>NY</stateOrCountry>
            <zipCode>10036</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>646-214-0700</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>EASYWEB INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jonathan</firstName>
                <lastName>Lewis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1180 Avenue of the Americas</street1>
                <street2>19th Floor</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10036</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <middleName>E</middleName>
                <lastName>Bagley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1180 Avenue of the Americas</street1>
                <street2>19th Floor</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10036</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Murray</firstName>
                <lastName>Brennan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Memorial Sloan Kettering Cancer Center</street1>
                <street2>1275 York Avenue</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10021</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>Anthony</middleName>
                <lastName>Cannon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>BBDO</street1>
                <street2>1285 Avenue of the Americas</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10019</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Wyche</firstName>
                <lastName>Fowler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 A Street NE</street1>
                <city>Washington</city>
                <stateOrCountry>DC</stateOrCountry>
                <zipCode>20002</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gary</firstName>
                <middleName>S</middleName>
                <lastName>Fragin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>4925 Arlington Avenue</street1>
                <city>Riverdale</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10471</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Timothy</firstName>
                <lastName>McInerney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>One Coventry Lane</street1>
                <city>Hopewell</city>
                <stateOrCountry>NJ</stateOrCountry>
                <zipCode>08525</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <lastName>Weiser</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1180 Avenue of the Americas</street1>
                <street2>Suite 1920</street2>
                <city>New York</city>
                <stateOrCountry>NY</stateOrCountry>
                <zipCode>10036</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-09-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Rodman &amp; Renshaw LLC</recipientName>
                <recipientCRDNumber>16415</recipientCRDNumber>
                <associatedBDName>Rodman &amp; Renshaw LLC</associatedBDName>
                <associatedBDCRDNumber>16415</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1251 Ave. of the Americas</street1>
                    <street2>20th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10020</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>IL</state>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Riverbank Capital Securities, Inc.</recipientName>
                <recipientCRDNumber>135310</recipientCRDNumber>
                <associatedBDName>Riverbank Capital Securities, Inc.</associatedBDName>
                <associatedBDCRDNumber>135310</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>689 Fifth Avenue</street1>
                    <street2>14th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AL</state>
                    <state>CA</state>
                    <state>CT</state>
                    <state>MS</state>
                    <state>NJ</state>
                    <state>NY</state>
                    <state>TX</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Griffin Securities</recipientName>
                <recipientCRDNumber>43229</recipientCRDNumber>
                <associatedBDName>Griffin Securities</associatedBDName>
                <associatedBDCRDNumber>43229</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>17 State Street</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10004</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5059527</totalOfferingAmount>
            <totalAmountSold>5059527</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>26</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>354167</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Excludes $26,587.84 in reimbursement of placement agent expenses.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ZIOPHARM ONCOLOGY INC</issuerName>
                <signatureName>/s/ R. Bagley</signatureName>
                <nameOfSigner>Richard E. Bagley</nameOfSigner>
                <signatureTitle>President, COO &amp; Treasurer</signatureTitle>
                <signatureDate>2009-09-29</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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