-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 HE1KLelOLeufZSOtio744vf1m+tzRfDPykF6YPUMtQoHECxJtf8AkiudSAvrkQUg
 qTGorKPN1p/jCNXVqNwUMQ==

<SEC-DOCUMENT>0001123292-09-000700.txt : 20090812
<SEC-HEADER>0001123292-09-000700.hdr.sgml : 20090812
<ACCEPTANCE-DATETIME>20090811174225
ACCESSION NUMBER:		0001123292-09-000700
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090812
DATE AS OF CHANGE:		20090811
EFFECTIVENESS DATE:		20090812

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARRAY BIOPHARMA INC
		CENTRAL INDEX KEY:			0001100412
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				841460811
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-118338
		FILM NUMBER:		091004771

	BUSINESS ADDRESS:	
		STREET 1:		3200 WALNUT STREET
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		3033816600

	MAIL ADDRESS:	
		STREET 1:		3200 WALNUT STREET
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001100412</cik>
        <entityName>ARRAY BIOPHARMA INC</entityName>
        <issuerAddress>
            <street1>3200 WALNUT STREET</street1>
            <street2></street2>
            <city>BOULDER</city>
            <stateOrCountry>CO</stateOrCountry>
            <zipCode>80301</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>3033816600</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>E.</middleName>
                <lastName>Conway</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>R.</firstName>
                <middleName>Michael</middleName>
                <lastName>Carruthers</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Snitnam</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kevin</firstName>
                <middleName></middleName>
                <lastName>Koch</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>R.</middleName>
                <lastName>Moore</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marvin</firstName>
                <middleName>H.</middleName>
                <lastName>Caruthers</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Francis</firstName>
                <middleName>J.</middleName>
                <lastName>Bullock</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kyle</firstName>
                <middleName>A.</middleName>
                <lastName>Lefkoff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Douglas</firstName>
                <middleName>E.</middleName>
                <lastName>Williams</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gil</firstName>
                <middleName>J.</middleName>
                <lastName>Van Lunsen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>L.</middleName>
                <lastName>Zabriskie</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Array BioPharma Inc.</street1>
                <street2>3200 Walnut Street</street2>
                <city>Boulder</city>
                <stateOrCountry>CO</stateOrCountry>
                <zipCode>80301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$25,000,001 - $100,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001123292-09-000548</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>0</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse>Warrants issued for 6,000,000 shares of common stock at $4.19 per share. Warrants previously issued for 6,000,000 shares of common stock at $3.65 per share. Common stock issuable upon exercise of foregoing warrants</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>2</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ARRAY BIOPHARMA INC</issuerName>
                <signatureName>R. Michael Carruthers</signatureName>
                <nameOfSigner>R. Michael Carruthers</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-08-11</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----