-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 O9Jbzg0sP8viaXG/bNziF5zoxghM5gE1A7XEnLb9F05S2UbeMACHRDKuRDcZHZq7
 HDTb0hNfXTupEOk+5QQFDg==

<SEC-DOCUMENT>0001077396-10-000004.txt : 20100223
<SEC-HEADER>0001077396-10-000004.hdr.sgml : 20100223
<ACCEPTANCE-DATETIME>20100223151946
ACCESSION NUMBER:		0001077396-10-000004
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100223
DATE AS OF CHANGE:		20100223
EFFECTIVENESS DATE:		20100223

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SOURCE PRECISION MEDICINE, INC.
		CENTRAL INDEX KEY:			0001077396
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-44353
		FILM NUMBER:		10625633

	BUSINESS ADDRESS:	
		STREET 1:		2500 CENTRAL AVENUE
		STREET 2:		SUITE H-2
		CITY:			BOUNDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		303-385-2700

	MAIL ADDRESS:	
		STREET 1:		2500 CENTRAL AVENUE
		STREET 2:		SUITE H-2
		CITY:			BOUNDER
		STATE:			CO
		ZIP:			80301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SOURCE BIOPHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000425

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SOURCE PRECISION MEDICINE INC
		DATE OF NAME CHANGE:	19990122
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001077396</cik>
        <entityName>SOURCE PRECISION MEDICINE, INC.</entityName>
        <issuerAddress>
            <street1>2500 CENTRAL AVENUE</street1>
            <street2>SUITE H-2</street2>
            <city>BOULDER</city>
            <stateOrCountry>CO</stateOrCountry>
            <zipCode>80301</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>303-385-2700</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>SOURCE BIOPHARMACEUTICALS INC</previousName>
            <previousName>SOURCE PRECISION MEDICINE INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Karl</firstName>
                <lastName>Wassmann</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>199 Wells Avenue</street1>
                <street2>Suite 209</street2>
                <city>Newton</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02459</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J. Terence</firstName>
                <lastName>Carleton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>288 Fox Hill Road</street1>
                <city>Needham</city>
                <stateOrCountry>MA</stateOrCountry>
                <zipCode>02492</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-02-12</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Series B Convertible Preferred Stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2000000</totalOfferingAmount>
            <totalAmountSold>1509123</totalAmountSold>
            <totalRemaining>490877</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>20</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>SOURCE PRECISION MEDICINE, INC.</issuerName>
                <signatureName>Robert Falloon</signatureName>
                <nameOfSigner>Robert Falloon</nameOfSigner>
                <signatureTitle>Vice President, Finance and Administration</signatureTitle>
                <signatureDate>2010-02-22</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----