-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 EJfceDNZNC+j/gIVH2Akx8VyywsmE4WlcI+JDWfeN7IjGi+g2LwWVhZn33P9D5Cq
 BHOgY/nAPBFrdz5l2f/lzA==

<SEC-DOCUMENT>0000950138-09-000805.txt : 20091210
<SEC-HEADER>0000950138-09-000805.hdr.sgml : 20091210
<ACCEPTANCE-DATETIME>20091210171550
ACCESSION NUMBER:		0000950138-09-000805
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091210
DATE AS OF CHANGE:		20091210
EFFECTIVENESS DATE:		20091210

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ISTO TECHNOLOGIES INC
		CENTRAL INDEX KEY:			0001052380
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-59318
		FILM NUMBER:		091234440

	BUSINESS ADDRESS:	
		STREET 1:		1155 OLIVETTE EXECUTIVE OFFICE PARKWAY
		STREET 2:		SUITE 200
		CITY:			OLIVETTE
		STATE:			MO
		ZIP:			63132
		BUSINESS PHONE:		314-995-6049

	MAIL ADDRESS:	
		STREET 1:		1155 OLIVETTE EXECUTIVE OFFICE PARKWAY
		STREET 2:		SUITE 200
		CITY:			OLIVETTE
		STATE:			MO
		ZIP:			63132
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001052380</cik>
        <entityName>ISTO TECHNOLOGIES INC</entityName>
        <issuerAddress>
            <street1>1155 OLIVETTE EXECUTIVE OFFICE PARKWAY</street1>
            <street2>SUITE 200</street2>
            <city>OLIVETTE</city>
            <stateOrCountry>MO</stateOrCountry>
            <zipCode>63132</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(314) 995-6049</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <lastName>Alafi, Ph.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Cheryl</firstName>
                <middleName>R.</middleName>
                <lastName>Blanchard</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tara</firstName>
                <lastName>Butler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joseph</firstName>
                <lastName>Feder</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dean</firstName>
                <lastName>Kappel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>J.</middleName>
                <lastName>Maloney, M.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <lastName>Melzer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mitchell</firstName>
                <lastName>Seyedin, Ph.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Scott</firstName>
                <lastName>Gill</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Garry</firstName>
                <lastName>Gage</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Penny</firstName>
                <lastName>White</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Blake</firstName>
                <lastName>Miles</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o ISTO Technologies, Inc.</street1>
                <street2>1155 Olivette Executive Office Parkway</street2>
                <city>Olivette</city>
                <stateOrCountry>MO</stateOrCountry>
                <zipCode>63132</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-12-02</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>10000000</totalOfferingAmount>
            <totalAmountSold>3272961</totalAmountSold>
            <totalRemaining>6727039</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>24</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ISTO TECHNOLOGIES INC</issuerName>
                <signatureName>/s/ Scott Gill</signatureName>
                <nameOfSigner>Scott Gill</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-12-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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